Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate.
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Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen speciesMemory in the B-cell compartment: antibody affinity maturationMemory B cells in transplantationStructural insights on the role of antibodies in HIV-1 vaccine and therapyAntibodies in HIV-1 vaccine development and therapyThe structural basis of repertoire shift in an immune response to phosphocholineTRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conservedSelective Ligand Recognition by a Diversity-Generating Retroelement Variable ProteinGermline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirusA structural basis for antigen recognition by the T cell-like lymphocytes of sea lampreyAntibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain ExchangedSomatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 NeutralizationStructure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological TheoryAssociation rate constants of ras-effector interactions are evolutionarily conservedTargeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune responseMultivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycansHumanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines.B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1Mechanisms of B-cell synapse formation predicted by Monte Carlo simulation.In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin.Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity.In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturationPredicting the kinetics of peptide-antibody interactions using a multivariate experimental design of sequence and chemical space.Isolation of anti-CD22 Fv with high affinity by Fv display on human cells.The SCHOOL of nature: I. Transmembrane signaling.Llama antibody fragments with cross-subtype human immunodeficiency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120Structural and thermodynamic approach to peptide immunogenicity.Deriving a germinal center lymphocyte migration model from two-photon data.Back to the future: recombinant polyclonal antibody therapeutics.High-affinity lamprey VLRA and VLRB monoclonal antibodiesGeneration of a family-specific phage library of llama single chain antibody fragments that neutralize HIV-1Optimality of mutation and selection in germinal centers.Analogous interactions in initiating complexes of the classical and lectin pathways of complementCD40-activated B cells induce anti-tumor immunity in vivo.Upregulated expression of B-cell antigen family tandem repeat proteins by Leishmania amastigotesBeyond natural antibodies: the power of in vitro display technologies.How advances in immunology provide insight into improving vaccine efficacy.
P2860
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P2860
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Affinity dependence of the B c ...... nd the importance of off-rate.
@en
type
label
Affinity dependence of the B c ...... nd the importance of off-rate.
@en
prefLabel
Affinity dependence of the B c ...... nd the importance of off-rate.
@en
P1433
P1476
Affinity dependence of the B c ...... nd the importance of off-rate.
@en
P2093
Batista FD
Neuberger MS
P304
P356
10.1016/S1074-7613(00)80580-4
P407
P577
1998-06-01T00:00:00Z