Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells.
about
Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange.A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1.Experimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell linesUse of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell culturesHuman artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblastsProliferation control strategies to improve productivity and survival during CHO based production culture : A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell linesConstraints on the transport and glycosylation of recombinant IFN-gamma in Chinese hamster ovary and insect cells.Epigenetic engineering of ribosomal RNA genes enhances protein production.Targeted toxin-based selectable drug-free enrichment of Mammalian cells with high transgene expression.Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticlesSystematic transfer of prokaryotic sensors and circuits to mammalian cellsTuning gene expression with synthetic upstream open reading frames.Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) systemStreptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice.A synthetic time-delay circuit in mammalian cells and miceVitamin H-regulated transgene expression in mammalian cells.Application of a reversible immortalization system for the generation of proliferation-controlled cell lines.Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices.MicroRNAs: recently discovered key regulators of proliferation and apoptosis in animal cells : Identification of miRNAs regulating growth and survival.Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes.Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin.The piggyBac-Based Gene Delivery System Can Confer Successful Production of Cloned Porcine Blastocysts with Multigene Constructs.Reward-based hypertension control by a synthetic brain-dopamine interface.Using cell engineering and omic tools for the improvement of cell culture processes.Regulated multicistronic expression technology for mammalian metabolic engineering.Engineering mammalian cells in bioprocessing - current achievements and future perspectives.Emerging biomedical applications of synthetic biology.CHO cells in biotechnology for production of recombinant proteins: current state and further potential.Perspectives in metabolic engineering: understanding cellular regulation towards the control of metabolic routes.Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells.Expression of the transcription factor GADD153 is an indicator of apoptosis for recombinant chinese hamster ovary (CHO) cells.Recombinant glycoprotein product quality in proliferation-controlled BHK-21 cells.Streptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells.Hyperosmotic stimulus study discloses benefits in ATP supply and reveals miRNA/mRNA targets to improve recombinant protein production of CHO cells.Cellular responses to individual amino-acid depletion in antibody-expressing and parental CHO cell lines.Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cells.Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation.Pharmacological-based translational induction of transgene expression in mammalian cells.A GFP-based screen for growth-arrested, recombinant protein-producing cells.
P2860
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P2860
Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Controlled proliferation by mu ...... f Chinese hamster ovary cells.
@en
type
label
Controlled proliferation by mu ...... f Chinese hamster ovary cells.
@en
prefLabel
Controlled proliferation by mu ...... f Chinese hamster ovary cells.
@en
P2093
P2860
P356
P1433
P1476
Controlled proliferation by mu ...... f Chinese hamster ovary cells.
@en
P2093
Dätwyler D
Fussenegger M
Schlatter S
P2860
P2888
P304
P356
10.1038/NBT0598-468
P577
1998-05-01T00:00:00Z