Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay.
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Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseasesTNF biology, pathogenic mechanisms and emerging therapeutic strategiesEpigenetics of inflammation, maternal infection, and nutritionEpigenetic contributions in the development of rheumatoid arthritisHDAC inhibitors and immunotherapy; a double edged sword?Histone deacetylases as targets for treatment of multiple diseasesHistone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammationPreclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro.Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytesEpigenetic enzymes are the therapeutic targets for CD4(+)CD25(+/high)Foxp3(+) regulatory T cellsMicroRNA-26b inhibits cell proliferation and cytokine secretion in human RASF cells via the Wnt/GSK-3β/β-catenin pathway.Epigenetics and autoimmune diseases.The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts.Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts.Natural indoles, indole-3-carbinol and 3,3'-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression.The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape.Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytesClass I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo.Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expressionPre-rheumatoid arthritis: predisposition and transition to clinical synovitis.Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.Epigenetics in autoimmune diseases with focus on type 1 diabetes.Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs.Perspectives on epigenetic-based immune intervention for rheumatic diseases.Monoclonal antibody treatments for rheumatoid arthritis.Epigenetics in rheumatoid arthritis: a primer for rheumatologists.Epigenetic-based immune intervention for rheumatic diseases.Emerging role of epigenetics in systemic sclerosis pathogenesis.Review article: selective histone deacetylase isoforms as potential therapeutic targets in inflammatory bowel diseases.Histone variants expression in peripheral blood mononuclear cells of patients with rheumatoid arthritis.Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages.Epigenetic drug discovery: breaking through the immune barrier.The acetyl code in rheumatoid arthritis and other rheumatic diseases.The Histone Modification Code in the Pathogenesis of Autoimmune DiseasesThe epigenome of synovial fibroblasts: an underestimated therapeutic target in rheumatoid arthritisEpigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.Epigenetics in the pathogenesis of RA.Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors.
P2860
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P2860
Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Histone deacetylase inhibitors ...... on by accelerating mRNA decay.
@en
type
label
Histone deacetylase inhibitors ...... on by accelerating mRNA decay.
@en
prefLabel
Histone deacetylase inhibitors ...... on by accelerating mRNA decay.
@en
P2093
P2860
P356
P1476
Histone deacetylase inhibitors ...... on by accelerating mRNA decay.
@en
P2093
Aleksander M Grabiec
Kris A Reedquist
Olexandr Korchynskyi
Paul P Tak
P2860
P304
P356
10.1136/ARD.2011.154211
P407
P577
2011-09-27T00:00:00Z