about
Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersSolution Structure and Membrane Binding of the Toxin Fst of the par Addiction ModuleInsights into the molecular evolution of oxytocin receptor ligand bindingCholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer.Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.Symmetric allosteric mechanism of hexameric Escherichia coli arginine repressor exploits competition between L-arginine ligands and resident arginine residues.Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein.Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients.Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelThe mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transportersPharmacological correction of misfolding of ABC proteins.Unifying concept of serotonin transporter-associated currentsRefinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding SitePore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.Comparative oncology: ErbB-1 and ErbB-2 homologues in canine cancer are susceptible to cetuximab and trastuzumab targeting.Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine TransportersAmphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphateNanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding SitesComputational models for prediction of interactions with ABC-transporters.Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates.A salt-bridge motif involved in ligand binding and large-scale domain motions of the maltose-binding protein.Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications.'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function.A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues.A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1)Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24CA salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.Molecular dynamics simulations of the Apo-, Holo-, and acyl-forms of Escherichia coli acyl carrier protein.Membrane-mediated effect on ion channels induced by the anesthetic drug ketamine.Molecular dynamics studies of a molecular switch in the glucocorticoid receptor.A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.Enantioselectivity of epoxide hydrolase catalysed oxirane ring opening: a 3D QSAR study.Computer modeling of polyleucine-based coiled coil dimers in a realistic membrane environment: insight into helix-helix interactions in membrane proteins.Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain.Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.Synergy of Molecular Dynamics and Isothermal Titration Calorimetry in Studies of Allostery
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Thomas Stockner
@ast
Thomas Stockner
@en
Thomas Stockner
@es
Thomas Stockner
@sl
type
label
Thomas Stockner
@ast
Thomas Stockner
@en
Thomas Stockner
@es
Thomas Stockner
@sl
prefLabel
Thomas Stockner
@ast
Thomas Stockner
@en
Thomas Stockner
@es
Thomas Stockner
@sl
P108
P1053
A-9509-2014
P106
P108
P21
P31
P3829
P496
0000-0002-7071-8283