Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.
about
Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in miceHsp90 inhibition ameliorates CD4(+) T cell-mediated acute Graft versus Host disease in mice.Obese donor mice splenocytes aggravated the pathogenesis of acute graft-versus-host disease via regulating differentiation of Tregs and CD4+ T cell induced-type I inflammation.
P2860
Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.
description
2015 nî lūn-bûn
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2015年の論文
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name
Combined PI3K/Akt and Hsp90 ta ...... e T cells and increases Tregs.
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type
label
Combined PI3K/Akt and Hsp90 ta ...... e T cells and increases Tregs.
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prefLabel
Combined PI3K/Akt and Hsp90 ta ...... e T cells and increases Tregs.
@en
P2093
P2860
P356
P1476
Combined PI3K/Akt and Hsp90 ta ...... e T cells and increases Tregs.
@en
P2093
Carsten Berges
Claudia Stuehler
Manik Chatterjee
Max S Topp
Michaela Kruhm
Nadine Winter
Nina Khanna
Ralf C Bargou
Sarah Zehnter
Tanja Bedke
P2860
P304
P356
10.1189/JLB.5A0814-413R
P577
2015-08-11T00:00:00Z