Molecular Docking, Molecular Dynamics, and Structure-Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists.

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A Computational Approach to Identify a Potential Alternative Drug With Its Positive Impact Toward PMP22.Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists.

P2860

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P2860

Molecular Docking, Molecular Dynamics, and Structure-Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists.

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http://www.wikidata.org/entity/Q41061564

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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2017年學術文章

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Molecular Docking, Molecular D ...... nt μ-Opioid Receptor Agonists.

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Molecular Docking, Molecular D ...... nt μ-Opioid Receptor Agonists.

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Molecular Docking, Molecular D ...... nt μ-Opioid Receptor Agonists.

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P1476

Molecular Docking, Molecular D ...... nt μ-Opioid Receptor Agonists.

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P2093

Stefan M Noha

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P2860

Structure-based discovery of opioid analgesics with reduced side effects.

Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

Development and validation of a genetic algorithm for flexible docking

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters.

Representation of target-bound drugs by computed conformers: implications for conformational libraries.

14-methoxymetopon, a potent opioid, induces no respiratory depression, less sedation, and less bradycardia than sufentanil in the dog.

In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel mu opioid analgesic with reduced propensity to alter motor function

14-Methoxymetopon, a very potent mu-opioid receptor-selective analgesic with an unusual pharmacological profile.

P304

1327-1337

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scholarly article

P356

10.1021/ACSCHEMNEURO.6B00460

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P433

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P478

http://www.w3.org/2001/XMLSchema#string

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Mariana Spetea

Helmut Schmidhammer

P577

2017-01-26T00:00:00Z

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P698

28125215

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opioid

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5481819

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Molecular Docking, Molecular Dynamics, and Structure-Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists.

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P2860

P2860

Molecular Docking, Molecular Dynamics, and Structure-Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists.

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type

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P921

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P1433

P1476

P2093

P2860

P304

P31

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P433

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P698

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P932