Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.

Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.

Item
http://www.wikidata.org/entity/Q41119063
Cloning and characterization of a family of proteins associated with MplThrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytesRole of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidyAn ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominanceThrombopoietin from beginning to end.From chronic immune thrombocytopenia to severe aplastic anemia: recent insights into the evolution of eltrombopag.Different mutations of the human c-mpl gene indicate distinct haematopoietic diseasesBCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis.Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway.Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors.Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e.SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation.
P2860

Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.

Item
http://www.wikidata.org/entity/Q41119063
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Thrombopoietin induces activat ...... the protooncoprotein p120CBL.
@en
type
label
Thrombopoietin induces activat ...... the protooncoprotein p120CBL.
@en
prefLabel
Thrombopoietin induces activat ...... the protooncoprotein p120CBL.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P356
P1433
P1476
Thrombopoietin induces activat ...... the protooncoprotein p120CBL.
@en
P2093
P2860
P304
P31
P356
10.1002/(SICI)1097-4652(199704)171:1<28::AID-JCP4>3.0.CO;2-J
P433
P478
P577
P698