Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach.
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New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kineticsClozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism.Radioligand dissociation measurements: potential interference of rebinding and allosteric mechanisms and physiological relevance of the biological model systems.Drug-target residence time--a case for G protein-coupled receptors.On the 'micro'-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action.Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivoDual-point competition association assay: a fast and high-throughput kinetic screening method for assessing ligand-receptor binding kinetics.Structure-Affinity Relationships and Structure-Kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists.Characterization of Kinetic Binding Properties of Unlabeled Ligands via a Preincubation Endpoint Binding Approach.A two-state model for the kinetics of competitive radioligand binding.
P2860
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P2860
Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Estimation of the dissociation ...... competition binding approach.
@en
type
label
Estimation of the dissociation ...... competition binding approach.
@en
prefLabel
Estimation of the dissociation ...... competition binding approach.
@en
P2093
P2860
P1476
Estimation of the dissociation ...... competition binding approach.
@en
P2093
A Balendran
G Vauquelin
M Wennerberg
P2860
P304
P356
10.1111/J.1476-5381.2010.00931.X
P407
P577
2010-11-01T00:00:00Z