The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.
about
The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activationDistinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptorsSystematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassayAnalysis of transmembrane domains 1 and 4 of the human angiotensin II AT1 receptor by cysteine-scanning mutagenesis.The angiotensin II type 1 receptor and receptor-associated proteins.Construction of a yeast-based signaling biosensor for human angiotensin II type 1 receptor via functional coupling between Asn295-mutated receptor and Gpa1/Gi3 chimeric Gα.Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response.International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine scanning mutagenesis.Review: Structural requirements for signalling and regulation of AT1-receptors.Constitutive internalization of constitutively active agiotensin II AT(1A) receptor mutants is blocked by inverse agonists.Delineation of the structural basis for the activation properties of the dopamine D1 receptor subtypes.Structural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin.Increased peripheral resistance in heart failure: new evidence suggests an alteration in vascular smooth muscle function.Critical hydrogen bond formation for activation of the angiotensin II type 1 receptor.Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation.Activation induces structural changes in the liganded angiotensin II type 1 receptor.Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74.The fifth transmembrane domain of angiotensin II Type 1 receptor participates in the formation of the ligand-binding pocket and undergoes a counterclockwise rotation upon receptor activation.Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications.Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.The arrangement of the transmembrane helices in the secretin receptor family of G-protein-coupled receptors.Distinctions between non-peptide angiotensin II AT1-receptor antagonists.
P2860
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P2860
The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The conformational change resp ...... smembrane helices III and VII.
@en
type
label
The conformational change resp ...... smembrane helices III and VII.
@en
prefLabel
The conformational change resp ...... smembrane helices III and VII.
@en
P2093
P2860
P356
P1476
The conformational change resp ...... smembrane helices III and VII.
@en
P2093
P2860
P304
P356
10.1074/JBC.272.7.4245
P407
P577
1997-02-01T00:00:00Z