The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.
about
Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activityUpdate on the management of Philadelphia chromosome positive chronic myelogenous leukemia: role of nilotinibSignal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesisIdentification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia.Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes.Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity.A requirement for NF-kappaB activation in Bcr-Abl-mediated transformationOncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathwayTargeting paediatric acute lymphoblastic leukaemia: novel therapies currently in developmentRecommendations of the canadian consensus group on the management of chronic myeloid leukemia.BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitorsRegulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase.Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation.Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors.Bcr-Abl tyrosine kinase inhibitors- current status
P2860
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P2860
The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
The BCR-ABL tyrosine kinase in ...... s-dependent signaling pathway.
@en
type
label
The BCR-ABL tyrosine kinase in ...... s-dependent signaling pathway.
@en
prefLabel
The BCR-ABL tyrosine kinase in ...... s-dependent signaling pathway.
@en
P2093
P1433
P1476
The BCR-ABL tyrosine kinase in ...... s-dependent signaling pathway.
@en
P2093
P304
P407
P577
1996-12-01T00:00:00Z