Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis.
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Canine Models for Copper Homeostasis DisordersSynthetic fluorescent probes for studying copper in biological systemsCopper directs ATP7B to the apical domain of hepatic cells via basolateral endosomesBiphasic regulation of lysosomal exocytosis by oxidative stressIdentification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutantsPolarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.TFE3 regulates whole-body energy metabolism in cooperation with TFEB.Copper is an endogenous modulator of neural circuit spontaneous activity.Brief exposure to copper activates lysosomal exocytosisWilson's disease: a comprehensive review of the molecular mechanisms.Recognition- and reactivity-based fluorescent probes for studying transition metal signaling in living systems.Structural and functional hepatocyte polarity and liver disease.Transition metals activate TFEB in overexpressing cellsGene expression patterns in the progression of canine copper-associated chronic hepatitis.The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy.Microbial peptide de-coppers mitochondria: implications for Wilson disease.Rational Design of a Water-Soluble, Lipid-Compatible Fluorescent Probe for Cu(I) with Sub-Part-Per-Trillion Sensitivity.Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines.ROS and intracellular ion channels.The emerging role of lysosomes in copper homeostasis.The role of insufficient copper in lipid synthesis and fatty-liver disease.Analytical Methods for Imaging Metals in Biology: From Transition Metal Metabolism to Transition Metal Signaling.Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.Orchestration of dynamic copper navigation - new and missing pieces.The P2X4 purinergic receptor impacts liver regeneration after partial hepatectomy in mice through the regulation of biliary homeostasis.ATP7B expression confers multidrug resistance through drug sequestrationOrgan-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis.The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations.mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.Atp7a and Atp7b regulate copper homeostasis in developing male germ cells in mice.Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.A systems biology approach reveals new endoplasmic reticulum-associated targets for the correction of the ATP7B mutant causing Wilson disease.Production of Wilson Disease Model Rabbits with Homology-Directed Precision Point Mutations in the ATP7B Gene Using the CRISPR/Cas9 System.In Vivo Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease.Cystinosin-LKG rescues cystine accumulation and decreases apoptosis rate in cystinotic proximal tubular epithelial cells.
P2860
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P2860
Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Wilson disease protein ATP7B u ...... o maintain copper homeostasis.
@en
type
label
Wilson disease protein ATP7B u ...... o maintain copper homeostasis.
@en
prefLabel
Wilson disease protein ATP7B u ...... o maintain copper homeostasis.
@en
P2093
P2860
P50
P1433
P1476
Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis
@en
P2093
Antonietta Tarallo
Christopher J Chang
Elena V Polishchuk
Francesca Pane
Giancarlo Chesi
Giancarlo Parenti
Jefferson Chan
Mafalda Concilli
Nunzia Pastore
Roman S Polishchuk
P2860
P304
P356
10.1016/J.DEVCEL.2014.04.033
P407
P50
P577
2014-06-05T00:00:00Z