The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.
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Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c ratCodeine and Morphine MetabolismTrends in the pharmacology of opioids: implications for the pharmacotherapy of pain.Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception.Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites.Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes.Detection of morphine-3-sulfate and morphine-6-sulfate in human urine and plasma, and formation in liver cytosol.In vitro-in vivo correlations for drugs eliminated by glucuronidation: investigations with the model substrate zidovudine.Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration.Sex differences in opioid analgesia: clinical and experimental findings.Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients.Scaling factors for the in vitro-in vivo extrapolation (IV-IVE) of renal drug and xenobiotic glucuronidation clearanceMorphine-6-glucuronide (M6G) for postoperative pain relief.Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administrationPharmacogenetic insights into codeine analgesia: implications to pediatric codeine use.The TLR4-Active Morphine Metabolite Morphine-3-Glucuronide Does Not Elicit Macrophage Classical Activation In Vitro.Application of fixed exponent 0.75 to the prediction of human drug clearance: an inaccurate and misleading concept.Metabolism of drugs of abuse by cytochromes P450.Why do metabolites circulate?Intracerebroventricular opioids for intractable pain.The challenges of LC-MS/MS analysis of opiates and opioids in urine.Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs.An observational study examining the effects of a surgically induced inflammatory response on the distribution of morphine and its metabolites into cerebrospinal fluid.Acute impairing effects of morphine related to driving: A systematic review of experimental studies to define blood morphine concentrations related to impairment in opioid-naïve subjects.Relationships between plasma concentrations of morphine, morphine-3-glucuronide, morphine-6-glucuronide, and intravenous morphine titration outcomes in the postoperative period.Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditionsRelationship between plasma concentrations of morphine and its metabolites and pain in cancer patients.Pharmacokinetics of morphine and its glucuronidated metabolites in burn injuries.Hydrophilic interaction LC-MS/MS analysis of opioids in urine: significance of glucuronide metabolites.Challenges and Opportunities with Predicting in Vivo Phase II Metabolism via Glucuronidation from in Vitro Data.Profiles in drug metabolism and toxicology: Richard Tecwyn Williams (1909-1979).Induction of morphine-6-glucuronide synthesis by heroin self-administration in the rat.Pharmacokinetics of morphine and its metabolites in freshwater rainbow trout (Oncorhynchus mykiss).Relation between blood- and urine-amphetamine concentrations in impaired drivers as influenced by urinary pH and creatinine.Simultaneous determination of morphine-6-d-glucuronide, morphine-3-d-glucuronide and morphine in human plasma and urine by ultra-performance liquid chromatography-tandem mass spectrometry: Application to M6G injection pharmacokinetic study.Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy.Morphine and heroin differentially modulate in vivo hippocampal LTP in opiate-dependent rat.Pharmacological Effects of a Monoclonal Antibody against 6-Monoacetylmorphine upon Heroin-Induced Locomotor Activity and Pharmacokinetics in Mice.
P2860
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P2860
The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
The disposition of morphine an ...... cological effects of morphine.
@en
type
label
The disposition of morphine an ...... cological effects of morphine.
@en
prefLabel
The disposition of morphine an ...... cological effects of morphine.
@en
P2860
P1476
The disposition of morphine an ...... acological effects of morphine
@en
P2093
A A Somogyi
R L Nation
P2860
P304
P356
10.3109/03602539608994011
P407
P50
P577
1996-08-01T00:00:00Z