FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination - Wikidata - wikimedia - TriplyDB

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

http://www.wikidata.org/entity/Q41182606

about

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling The Ikaros family of zinc-finger proteins Signaling by the phosphoinositide 3-kinase family in immune cells miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion Radiotherapy Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals PI3Kδ and primary immunodeficiencies.Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells.Lenalidomide, Thalidomide, and Pomalidomide Reactivate the Epstein-Barr Virus Lytic Cycle through Phosphoinositide 3-Kinase Signaling and Ikaros Expression.Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.Assembly and Function of the Precursor B-Cell Receptor.Splicing in immune cells-mechanistic insights and emerging topics.MK5 activates Rag transcription via Foxo1 in developing B cells.Human pre-B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP-kinase signalling pathways.Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.PI3K induces B-cell development and regulates B cell identity.Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD.PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses.Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.Potent antitumor effect of combination therapy with sub-optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma.

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P2860

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

http://www.wikidata.org/entity/Q41182606

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

@yue

2012年論文

@zh-hant

2012年論文

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2012年論文

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2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

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2012年论文

@zh-cn

name

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

@en

type

label

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

@en

prefLabel

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

@en

P1433

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Journal of Experimental Medicine

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FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

@en

P2093

Alabbas Alkhatib

http://www.w3.org/2001/XMLSchema#string

Cathrin Eschbach

http://www.w3.org/2001/XMLSchema#string

Eva Hug

http://www.w3.org/2001/XMLSchema#string

Fabian Köhler

http://www.w3.org/2001/XMLSchema#string

Hassan Jumaa

http://www.w3.org/2001/XMLSchema#string

Hemin Faraidun

http://www.w3.org/2001/XMLSchema#string

Markus Werner

http://www.w3.org/2001/XMLSchema#string

Sebastian Herzog

http://www.w3.org/2001/XMLSchema#string

Thomas Wossning

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

AKT/PKB signaling: navigating downstream

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

PI3K in lymphocyte development, differentiation and activation

Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression

B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5

The Ikaros gene is required for the development of all lymphoid lineages

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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395-406

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scholarly article

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10.1084/JEM.20110216

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2

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209

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2012-01-30T00:00:00Z

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221792503

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22291095

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3280865

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