FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
about
PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signallingThe Ikaros family of zinc-finger proteinsSignaling by the phosphoinositide 3-kinase family in immune cellsmiR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammationActivation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodiesFOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion RadiotherapyFunction of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemiaIndependent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signalsPI3Kδ and primary immunodeficiencies.Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells.Lenalidomide, Thalidomide, and Pomalidomide Reactivate the Epstein-Barr Virus Lytic Cycle through Phosphoinositide 3-Kinase Signaling and Ikaros Expression.Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.Assembly and Function of the Precursor B-Cell Receptor.Splicing in immune cells-mechanistic insights and emerging topics.MK5 activates Rag transcription via Foxo1 in developing B cells.Human pre-B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP-kinase signalling pathways.Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.PI3K induces B-cell development and regulates B cell identity.Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD.PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses.Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.Potent antitumor effect of combination therapy with sub-optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma.
P2860
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P2860
FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
@en
type
label
FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
@en
prefLabel
FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
@en
P2093
P2860
P356
P1476
FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
@en
P2093
Alabbas Alkhatib
Cathrin Eschbach
Fabian Köhler
Hassan Jumaa
Hemin Faraidun
Markus Werner
Sebastian Herzog
Thomas Wossning
P2860
P304
P356
10.1084/JEM.20110216
P407
P577
2012-01-30T00:00:00Z