Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness.
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Structural basis for the function and inhibition of an influenza virus proton channelThe Influenza M2 Ectodomain Regulates the Conformational Equilibria of the Transmembrane Proton Channel: Insights from Solid-State Nuclear Magnetic ResonanceSolid-State NMR Investigation of the Conformation, Proton Conduction, and Hydration of the Influenza B Virus M2 Transmembrane Proton ChannelCryoprotection of lipid membranes for high-resolution solid-state NMR studies of membrane peptides and proteins at low temperature.Membrane protein structure and dynamics from NMR spectroscopy.Paramagnetic Cu(II) for probing membrane protein structure and function: inhibition mechanism of the influenza M2 proton channel.Structural basis for proton conduction and inhibition by the influenza M2 protein.pH-dependent conformation, dynamics, and aromatic interaction of the gating tryptophan residue of the influenza M2 proton channel from solid-state NMRDrug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR.Conformational analysis of the full-length M2 protein of the influenza A virus using solid-state NMR.Proton Transport Mechanism of M2 Proton Channel Studied by Laser-Induced pH JumpNMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel.Proton association constants of His 37 in the Influenza-A M218-60 dimer-of-dimers.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesViral miniproteinsMechanism of influenza A M2 transmembrane domain assembly in lipid membranesInvestigation of the curvature induction and membrane localization of the influenza virus M2 protein using static and off-magic-angle spinning solid-state nuclear magnetic resonance of oriented bicelles.Cholesterol-Dependent Conformational Exchange of the C-Terminal Domain of the Influenza A M2 Protein.Structural Influences: Cholesterol, Drug, and Proton Binding to Full-Length Influenza A M2 Protein.Efficient DNP NMR of membrane proteins: sample preparation protocols, sensitivity, and radical location.Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cellsTransmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.Acid activation mechanism of the influenza A M2 proton channel.Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction.Conformational disorder of membrane peptides investigated from solid-state NMR line widths and line shapes.Influenza M2 Transmembrane Domain Senses Membrane Heterogeneity and Enhances Membrane Curvature.Structural Basis for Asymmetric Conductance of the Influenza M2 Proton Channel Investigated by Solid-State NMR Spectroscopy.Conformational Response of Influenza A M2 Transmembrane Domain to Amantadine Drug Binding at Low pH (pH 5.5).Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling.Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein.Influenza A Virus M2 Protein: Roles from Ingress to Egress.A Budding-Defective M2 Mutant Exhibits Reduced Membrane Interaction, Insensitivity to Cholesterol, and Perturbed Interdomain Coupling.Conformation and topology of diacylglycerol kinase in E.coli membranes revealed by solid-state NMR spectroscopy.Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers.
P2860
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P2860
Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Conformational plasticity of t ...... nding, and membrane thickness.
@en
type
label
Conformational plasticity of t ...... nding, and membrane thickness.
@en
prefLabel
Conformational plasticity of t ...... nding, and membrane thickness.
@en
P2860
P1476
Conformational plasticity of t ...... inding, and membrane thickness
@en
P2093
Fanghao Hu
Wenbin Luo
P2860
P304
P356
10.1016/J.BBAMEM.2010.09.014
P577
2010-09-29T00:00:00Z