Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells. - Wikidata - wikimedia - TriplyDB

Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells.

Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells.

http://www.wikidata.org/entity/Q41200952

about

Epigenetic regulators and their impact on therapy in acute myeloid leukemia Functions of TET Proteins in Hematopoietic Transformation Connections between TET proteins and aberrant DNA modification in cancer TET2 gene mutation is unfavorable prognostic factor in cytogenetically normal acute myeloid leukemia patients with NPM1+ and FLT3-ITD - mutations.Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0 The curious origins of angioimmunoblastic T-cell lymphoma TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.TET proteins and 5-methylcytosine oxidation in hematological cancers DNA methylation and hydroxymethylation in hematologic differentiation and transformation.The Yin and Yang of Chromatin Dynamics In Stem Cell Fate Selection Alterations of 5-hydroxymethylcytosine in human cancers.Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia.TET2 as an epigenetic master regulator for normal and malignant hematopoiesis.Multistep tumorigenesis in peripheral T cell lymphoma.Dysregulation of TET2 in hematologic malignancies.Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.Myeloid neoplasms with germ line RUNX1 mutation.Epigenetic dysregulation of hematopoietic stem cells and preleukemic state.The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence.Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice.Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele.Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells.Tracking hematopoietic precursor division ex vivo in real time.

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Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells.

http://www.wikidata.org/entity/Q41200952

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Tet2 disruption leads to enhan ...... iver hematopoietic stem cells.

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Tet2 disruption leads to enhan ...... iver hematopoietic stem cells.

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Tet2 disruption leads to enhan ...... iver hematopoietic stem cells.

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Scientific Reports

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Tet2 disruption leads to enhan ...... iver hematopoietic stem cells.

@en

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Hideaki Nakajima

http://www.w3.org/2001/XMLSchema#string

Hiroyoshi Kunimoto

http://www.w3.org/2001/XMLSchema#string

Ken Sadahira

http://www.w3.org/2001/XMLSchema#string

Masatoshi Sakurai

http://www.w3.org/2001/XMLSchema#string

Shinichiro Okamoto

http://www.w3.org/2001/XMLSchema#string

Yasuo Ikeda

http://www.w3.org/2001/XMLSchema#string

Yumi Fukuchi

http://www.w3.org/2001/XMLSchema#string

P2860

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Recurring mutations found by sequencing an acute myeloid leukemia genome

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

An integrated genomic analysis of human glioblastoma multiforme

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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10.1038/SREP00273

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2

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2012-02-17T00:00:00Z

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221852562

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22355785

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3281275

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