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Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingStructural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFbInsights into the low adhesive capacity of human T-cadherin from the NMR structure of Its N-terminal extracellular domainStructural Basis for the Association of the Redox-sensitive Target of Rapamycin FATC Domain with Membrane-mimetic MicellesStructure, Dynamics, Lipid Binding, and Physiological Relevance of the Putative GTPase-binding Domain of Dictyostelium Formin CStructure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1Structure of amyloid A4-(1-40)-peptide of Alzheimer's diseaseNMR structure of a parallel homotrimeric coiled coilA Rigorous and Efficient Method To Reweight Very Large Conformational Ensembles Using Average Experimental Data and To Determine Their Relative Information Content.Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides.NMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK)Characterization of residue-dependent differences in the peripheral membrane association of the FATC domain of the kinase 'target of rapamycin' by NMR and CD spectroscopy.Oxidative Unfolding of the Rubredoxin Domain and the Natively Disordered N-terminal Region Regulate the Catalytic Activity of Mycobacterium tuberculosis Protein Kinase G.One short cysteine-rich sequence pattern - two different disulfide-bonded structures - a molecular dynamics simulation study.A fast and simple method for probing the interaction of peptides and proteins with lipids and membrane-mimetics using GB1 fusion proteins and NMR spectroscopy.Characterization of the immersion properties of the peripheral membrane anchor of the FATC domain of the kinase "target of rapamycin" by NMR, oriented CD spectroscopy, and MD simulations.The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability.A fast and simple method to prepare the FKBP-rapamycin binding domain of human target of rapamycin for NMR binding assays.NMR analysis of the backbone dynamics of the small GTPase Rheb and its interaction with the regulatory protein FKBP38.In support of the BMRB.Target of rapamycin FATC domain as a general membrane anchor: The FKBP-12 like domain of FKBP38 as a case study.The FKBP-rapamycin binding domain of human TOR undergoes strong conformational changes in the presence of membrane mimetics with and without the regulator phosphatidic acid.1H, 15N, and 13C chemical shift assignments of the micelle immersed FAT C-terminal (FATC) domains of the human protein kinases ataxia-telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) fused to the B1 domain oChemical shift assignment of the intrinsically disordered N-terminus and the rubredoxin domain in the folded metal bound and unfolded oxidized state of mycobacterial protein kinase G.Subtype-specific modulation of estrogen receptor-coactivator interaction by phosphorylation.A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1.Expression and purification of the natively disordered and redox sensitive metal binding regions of Mycobacterium tuberculosis protein kinase G.1H, 13C, and 15N chemical shift assignments for the N-terminal extracellular domain of T-cadherinResidual Dipolar Couplings in Short Peptides Reveal Systematic Conformational Preferences of Individual Amino AcidsNMR assignment of the Cyclin T-binding domain of human Hexim11H, 15N, and 13C assignments of the N-terminal activation domain of Dictyostelium discoideum Formin CContributions of the ionization states of acidic residues to the stability of the coiled coil domain of matrilin-1NMR- and MD simulation-based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated
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description
hulumtuese
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researcher
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wetenschapper
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հետազոտող
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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Sonja A Dames
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P106
P21
P31
P496
0000-0001-7495-6943