Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
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Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil.Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibitionPositive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working strokeControlling load-dependent kinetics of β-cardiac myosin at the single-molecule levelProlonged cross-bridge binding triggers muscle dysfunction in a model of myosin-based hypertrophic cardiomyopathy
P2860
Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
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Mechanistic and structural bas ...... duction by omecamtiv mecarbil.
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type
label
Mechanistic and structural bas ...... duction by omecamtiv mecarbil.
@en
prefLabel
Mechanistic and structural bas ...... duction by omecamtiv mecarbil.
@en
P2860
P50
P1476
Mechanistic and structural bas ...... duction by omecamtiv mecarbil.
@en
P2093
Fady I Malik
Julien Robert-Paganin
P2860
P2888
P356
10.1038/S41467-017-00176-5
P407
P577
2017-08-04T00:00:00Z