Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation.
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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodiaMSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblastsTNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeletonGene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent streCdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylationSPECs, small binding proteins for Cdc42Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actinInvolvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyreneMADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinaseMyotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganizationSelective interaction of JNK protein kinase isoforms with transcription factorsNck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinaseSH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuliMolecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brainNIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domainThe MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathwaysTyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cellsAjuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisionsThe MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosisTANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathwayThe Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesThe PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organizationExpression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexesMKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathwayIQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilamentsStructure and mutagenesis of the Dbl homology domainHsl7p, a negative regulator of Ste20p protein kinase in the Saccharomyces cerevisiae filamentous growth-signaling pathway.Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast.Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-CellsRin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiationA tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteinsMEKK1 binds raf-1 and the ERK2 cascade componentsThe Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor
P2860
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P2860
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Cdc42 and PAK-mediated signali ...... ted protein kinase activation.
@en
type
label
Cdc42 and PAK-mediated signali ...... ted protein kinase activation.
@en
prefLabel
Cdc42 and PAK-mediated signali ...... ted protein kinase activation.
@en
P2093
P356
P1476
Cdc42 and PAK-mediated signali ...... ted protein kinase activation.
@en
P2093
P304
27995-27998
P356
10.1074/JBC.270.47.27995
P407
P577
1995-11-01T00:00:00Z