Vitamin K-dependent carboxylase: influence of the "propeptide" region on enzyme activity.
about
Effect of vitamin K-dependent protein precursor propeptide, vitamin K hydroquinone, and glutamate substrate binding on the structure and function of {gamma}-glutamyl carboxylaseVitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylaseMutagenesis of vitamin K-dependent carboxylase demonstrates a carboxyl terminus-mediated interaction with vitamin K hydroquinone.Biochemical characterization of Drosophila gamma-glutamyl carboxylase and its role in fly development.Osteocalcin binds tightly to the gamma-glutamylcarboxylase at a site distinct from that of the other known vitamin K-dependent proteins.A conserved region of human vitamin K-dependent carboxylase between residues 393 and 404 is important for its interaction with the glutamate substrate.Binding of the factor IX gamma-carboxyglutamic acid domain to the vitamin K-dependent gamma-glutamyl carboxylase active site induces an allosteric effect that may ensure processive carboxylation and regulate the release of carboxylated product.Expression and characterization of the naturally occurring mutation L394R in human gamma-glutamyl carboxylase.
P2860
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P2860
Vitamin K-dependent carboxylase: influence of the "propeptide" region on enzyme activity.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Vitamin K-dependent carboxylase: influence of the "propeptide" region on enzyme activity.
@en
type
label
Vitamin K-dependent carboxylase: influence of the "propeptide" region on enzyme activity.
@en
prefLabel
Vitamin K-dependent carboxylase: influence of the "propeptide" region on enzyme activity.
@en
P2093
P1476
Vitamin K-dependent carboxylase: influence of the "propeptide" region on enzyme activity.
@en
P2093
P304
P356
10.1016/0003-9861(89)90472-4
P407
P577
1989-11-01T00:00:00Z