Demyelination induced by Theiler's virus: influence of the H-2 haplotype.
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Theiler's virus infection: a model for multiple sclerosisHuman HLA-DR Transgenes Protect Mice from Fatal Virus-Induced Encephalomyelitis and Chronic DemyelinationPro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating diseaseSusceptibility and resistance to poliovirus-induced paralysis of inbred mouse strainsAnatomical and Cellular Requirements for the Activation and Migration of Virus-Specific CD8+ T Cells to the Brain during Theiler's Virus InfectionTheiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J miceAbsence of internal ribosome entry site-mediated tissue specificity in the translation of a bicistronic transgenePrevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosisQuantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination.HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosisSpontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis.CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosisProtection against lethal encephalomyocarditis virus infection in the absence of serum-neutralizing antibodies.H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virusViral load increases in SJL/J mice persistently infected by Theiler's virus after inactivation of the beta(2)m gene.A critical role for virus-specific CD8(+) CTLs in protection from Theiler's virus-induced demyelination in disease-susceptible SJL mice.A spontaneous low-pathogenic variant of Theiler's virus contains an amino acid substitution within the predominant VP1(233-250) T-cell epitope.Rapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells.The majority of infiltrating CD8+ T cells in the central nervous system of susceptible SJL/J mice infected with Theiler's virus are virus specific and fully functional.Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelinationDifferences in avidity and epitope recognition of CD8(+) T cells infiltrating the central nervous systems of SJL/J mice infected with BeAn and DA strains of Theiler's murine encephalomyelitis virusBone marrow chimeras reveal non-H-2 hematopoietic control of susceptibility to Theiler's virus persistent infectionChromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse.Preferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 miceMajor histocompatibility complex heterozygote superiority during coinfection.The level of viral infection of antigen-presenting cells correlates with the level of development of Theiler's murine encephalomyelitis virus-induced demyelinating disease.Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virusQuantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruptionTransgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosisAn elite controller of picornavirus infection targets an epitope that is resistant to immune escapeInjection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination.A novel all-trans retinoic acid derivative inhibits proliferation and induces differentiation of human gastric carcinoma xenografts via up-regulating retinoic acid receptor βInfection of class II-deficient mice by the DA strain of Theiler's virus.Major linear antibody epitopes and capsid proteins differentially induce protective immunity against Theiler's virus-induced demyelinating disease.Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice.Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region.Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.Chimeric Theiler's virus with altered tropism for the central nervous systemAnalysis of antibody responses to predominant linear epitopes of Theiler's murine encephalomyelitis virus.
P2860
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P2860
Demyelination induced by Theiler's virus: influence of the H-2 haplotype.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
Demyelination induced by Theiler's virus: influence of the H-2 haplotype.
@en
type
label
Demyelination induced by Theiler's virus: influence of the H-2 haplotype.
@en
prefLabel
Demyelination induced by Theiler's virus: influence of the H-2 haplotype.
@en
P1476
Demyelination induced by Theiler's virus: influence of the H-2 haplotype.
@en
P2093
P304
P407
P577
1985-09-01T00:00:00Z