Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells - Wikidata - wikimedia - TriplyDB

Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells

Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells

http://www.wikidata.org/entity/Q41387605

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PML nuclear bodies Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression Old cells, new tricks: chromatin structure in senescence Noncoding RNA control of cellular senescence The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci Global gene profiling of aging lungs in Atp8b1 mutant mice Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia VentX trans-activates p53 and p16ink4a to regulate cellular senescence Activation of Wnt/β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a.A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging.Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci.The essence of senescence.PML-mediated signaling and its role in cancer stem cells.Three-dimensional genome architecture: players and mechanisms.Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition.HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.A novel anti-proliferative role of HMGA2 in induction of apoptosis through caspase 2 in primary human fibroblast cells Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging.The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence.Molecular mechanisms underlying hepatocellular carcinoma A decline in Wnt3a signaling is necessary for mesenchymal stem cells to proceed to replicative senescence Effects of age and gender on WNT gene expression in human bone marrow stromal cells Cellular senescence and organismal aging.Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.Global heterochromatin loss: a unifying theory of aging?The National Lung Matrix Trial: translating the biology of stratification in advanced non-small-cell lung cancer.Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus.Changes in mitotic reorientation and Wnt/AR signaling in rat prostate epithelial cells exposed to subchronic testosterone.BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss Aging by epigenetics--a consequence of chromatin damage?

P2860

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P2860

Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells

http://www.wikidata.org/entity/Q41387605

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Brad Zerlanko

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Gowrishankar Banumathy

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Peter D Adams

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Rugang Zhang

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Xiaofen Ye

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P2860

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation

Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly

Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

Molecular dissection of formation of senescence-associated heterochromatin foci

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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