Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
about
Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiencyCloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cellsFunctional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylationDifferent interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferationFunctional cleavage of the common cytokine receptor gamma chain (gammac) by calpainJanus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Therapeutic Potential of Hyporesponsive CD4(+) T Cells in AutoimmunityInnate and adaptive immune cells in the tumor microenvironmentCancer immunotherapyCharacterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activationCIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signalingTob is a negative regulator of activation that is expressed in anergic and quiescent T cellsLow-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape.Rational combinations of immunotherapeutics that target discrete pathways.Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activityStaphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription (Stat proteins)Immunoregulatory functions of mTOR inhibition.Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation.The significance of tetramerization in promoter recruitment by Stat5.Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.Interleukin 2 signaling involves the phosphorylation of Stat proteins.Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.Mechanisms of interleukin-10-mediated immune suppression.Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signalingDelineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.T-cell tolerance and autoimmune diabetes.Cytokines and immunodeficiency diseases.Macroautophagy regulates energy metabolism during effector T cell activation.The therapeutic potential of costimulatory blockade with CTLA4Ig in rheumatoid arthritis.Response of human intestinal lamina propria T lymphocytes to interleukin 12: additive effects of interleukin 15 and 7Targeting the Jak/STAT pathway for immunosuppression.Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cellsInterleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit.Activation of the Jak3 pathway and myeloid differentiation.Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13.Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.Models of T cell anergy: is there a common molecular mechanism?
P2860
Q22008480-4177E656-2ADA-4E0A-BF0B-15025A1ACCF5Q24311526-54E4FF8E-8FA7-4EF3-9F7A-D034A8CA789DQ24522782-4BC3A789-E1AE-4875-A189-B32D795ECDB2Q24567993-2E02B011-7FCF-49BB-83F1-39678CB3A1C7Q24655060-7825BE12-1183-4982-A21F-A9706563CE13Q24806655-A9E794E3-B233-4470-BA5B-FA84A9F5C6FFQ26781243-56FFF2E1-E2DD-49A6-9070-4BFBFA54F9E7Q27008342-5DA7ADAA-A5F9-45CD-B3BB-A9C493417233Q27026870-86CC3EC1-6531-478F-8C5A-1923A2DB9664Q28142632-BBD3DE1B-D6C2-486E-8E2B-4DCF651FA324Q28145666-28CEA6FA-478F-4C42-95EA-8822E0037362Q28203889-EDEEEFF6-A18B-4A13-8413-8260475C539DQ30363260-CDA34BE9-354F-4C05-8CA5-A21642E304BBQ33606144-B2C5EA2F-4A72-4601-8FD1-0FA033A9A5F8Q33731594-1FFFBAA5-9AC9-4C37-9D9D-6AE205A19794Q33748769-186B6E48-7F6C-41E5-B574-2378EFB7A454Q33761278-94FB129E-F9D4-4F4B-945A-56A296A1176AQ33782891-1E98E896-CF2D-4600-84D3-4C86AC99954AQ33957422-BF7EFA9C-853F-427F-B885-495B55AA2903Q33961743-9A4A192D-ABF6-4222-BAC2-1DC5774246C1Q34007160-F9B33088-C695-4A97-8BBA-84FEECD3BF10Q34148749-AF45A2FB-7EF8-4AA9-9226-53D306D7585BQ34229092-78A9B86B-97BC-4891-81FE-36149D793DD1Q34285968-B3E8E736-6CC2-4225-A367-EE9ED9EE982EQ34320405-212AF90D-52D6-4EE2-B938-7556D2AB55FDQ34464999-73994F4E-794B-4734-AF65-A744848ADC30Q34552317-97C50767-F352-4315-B9B7-D50FBC19CDFAQ34572193-DAEA3094-CCED-49B9-A282-082EC640D3F5Q34615092-3EBA46AF-988E-4B60-BB0A-86B12F743614Q35094697-991DD3E0-B71F-450A-BD0E-B68FBD9F8E6EQ35353309-8A8416F7-FF51-474E-A425-EF00F607C1C7Q35579377-1B4AC153-5D78-4520-BAFD-1B94D7A061F9Q35763367-189FCA59-7FF4-4508-A18C-263FCF7E850AQ35907478-C81DFD7D-613E-41DD-83AE-71AF345A1C00Q35994891-B0D3B8E2-B84E-462F-BD12-B108CF743332Q36011208-83087321-3986-4A3D-B255-6B37064212C2Q36026082-0950B1F9-5E57-43C8-AECC-E0BAFAFC6276Q36234760-40D30203-F19E-4994-BF26-940FB87A0AE5Q36365418-8C6BEEE3-2766-4A3A-B043-FC904D89CD6FQ36366967-1B3B5C99-0C4D-42FB-89B9-E4FA30E91636
P2860
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
@en
type
label
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
@en
prefLabel
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
@en
P2093
P356
P1433
P1476
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
@en
P2093
A D D'Andrea
D L Barber
G J Freeman
G M Bernstein
J G Gribben
L M Nadler
V A Boussiotis
P304
P356
10.1126/SCIENCE.7973657
P407
P50
P577
1994-11-01T00:00:00Z