Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity - Wikidata - wikimedia - TriplyDB

Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity

Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity

http://www.wikidata.org/entity/Q41474854

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The role of dexamethasone in the modification of misonidazole pharmacokinetics No significant effect of cimetidine on the pharmacokinetics of misonidazole in man No significant effect of metoclopramide on misonidazole elimination in man.A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo.Phenytoin-induced changes in the pharmacokinetics of misonidazole in radiotherapy patients.The role of microsomal enzyme inducers in the reduction of misonidazole neurotoxicity.CB 1954 revisited. I. Disposition kinetics and metabolism.Combined modality treatment of operated astrocytomas grade 3 and 4. A prospective and randomized study of misonidazole and radiotherapy with two different radiation schedules and subsequent CCNU chemotherapy. Stage II of a prospective multicenter tr Final report on the United States Phase I Clinical Trial of the hypoxic cell radiosensitizer, misonidazole (Ro-07-0582; NSC #261037).

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Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity

http://www.wikidata.org/entity/Q41474854

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1980 nî lūn-bûn

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P2860

Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice

Liver size and indices of drug metabolism in epileptics

Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.

Distribution of misonidazole in human tumours and normal tissues.

Peripheral neuropathy related to misonidazole: incidence and pathology.

The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum.

Radiosensitization by misonidazole (Ro 07-0582). The importance of timing and tumor concentration of sensitizer.

Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses

Hypoxic sensitizers: radiobiological studies at the cellular level.

Pharmacological implications of microsomal enzyme induction.

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