Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing.
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Lactate: A key metabolite in the intercellular metabolic interplay.Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and DysfunctionMechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinismMitochondrial pyruvate transport: a historical perspective and future research directionsPhysical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cellsStreptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicityMitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic isletsMathematical model of metabolism and electrophysiology of amino acid and glucose stimulated insulin secretion: in vitro validation using a β-cell lineOverexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exerciseQuantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogrammingGlucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cellsPancreatic beta cells require NeuroD to achieve and maintain functional maturityDifferent metabolic responses in alpha-, beta-, and delta-cells of the islet of Langerhans monitored by redox confocal microscopy.The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult miceSecretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera.Beyond Warburg effect--dual metabolic nature of cancer cells.Structure, function and regulation of pyruvate carboxylase.Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretionIncreased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretionEffects of energy dissipation rate on islets of Langerhans: implications for isolation and transplantation.Insulin secretion and insulin-producing tumorsRaptor regulates functional maturation of murine beta cells.A stirred microchamber for oxygen consumption rate measurements with pancreatic isletsHypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cellsDominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cellsRegulation of insulin secretion: role of mitochondrial signalling.Glucose sensing in the pancreatic beta cell: a computational systems analysis.Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell.A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex.Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolismComparative Analysis of the Mitochondrial Physiology of Pancreatic β CellsHigh passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.Spatiotemporal correlations between cytosolic and mitochondrial Ca(2+) signals using a novel red-shifted mitochondrial targeted cameleonTissue-specific disallowance of housekeeping genes: the other face of cell differentiation.Surgical protocol involving the infusion of paramagnetic microparticles for preferential incorporation within porcine islets.MAFA controls genes implicated in insulin biosynthesis and secretionmiR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)
P2860
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P2860
Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Low lactate dehydrogenase and ...... tial role in nutrient sensing.
@en
type
label
Low lactate dehydrogenase and ...... tial role in nutrient sensing.
@en
prefLabel
Low lactate dehydrogenase and ...... tial role in nutrient sensing.
@en
P2093
P1476
Low lactate dehydrogenase and ...... ntial role in nutrient sensing
@en
P2093
C B Wollheim
J Tamarit-Rodriguez
M J MacDonald
P304
P407
P577
1994-02-01T00:00:00Z