Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro.Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cellsExtracellular ATP induces the release of calcium from intracellular stores without the activation of protein kinase C in Swiss 3T6 mouse fibroblasts.Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.Cloning of a receptor for amphibian [Phe13]bombesin distinct from the receptor for gastrin-releasing peptide: identification of a fourth bombesin receptor subtype (BB4).The 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization.Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factorProtein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxinTransient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung.Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells.Reduction in receptors for bombesin and epidermal growth factor in xenografts of human small-cell lung cancer after treatment with bombesin antagonist RC-3095.Effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude miceGrowth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. II. Two signaling pathways distinguished by pertussis toxin and a potential role for the ras oncogene.New perspectives in lung cancer. 2. Growth factors and lung cancer.Neuropeptides as cellular growth factors: role of multiple signalling pathways.Neuropeptide growth factors.A single in vivo administration of bombesin antagonist RC-3095 reduces the levels and mRNA expression of epidermal growth factor receptors in MXT mouse mammary cancersAbnormal protein kinase C down regulation and reduced substrate levels in non-phorbol ester-responsive 3T3-TNR9 cells.Alterations of G-protein coupling function in phosphoinositide signaling pathways of cells transformed by ras and other membrane-associated and cytoplasmic oncogenes.Role of peptide growth factors in asbestos-related human lung cancer.Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.Neuropeptide growth factors and cancer.Interaction of bombesin and related peptides with receptors on pancreatic acinar cells.Progress in the development of competitive bombesin antagonists.Kinetics and regulation of the tyrosine phosphorylation of epidermal growth factor receptor in intact A431 cells.Transcriptional down-regulation of MARCKS gene expression in immortalized hippocampal cells by lithium.Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism.Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serumA tyrosine protein kinase activated by bombesin in normal fibroblasts and small cell carcinomas.Internalization and degradation of peptides of the bombesin family in Swiss 3T3 cells occurs without ligand-induced receptor down-regulation.Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pHExtracellular ATP-induced regulation of epidermal growth factor signaling in cultured renal LLC-PK1 cells.Multisite phosphorylation of the 80 kDa (MARCKS) protein kinase C substrate in C3H/10T1/2 fibroblasts. Quantitative analysis of individual sites by solid-phase microsequencing.Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulationActivation of protein kinase C by phorbol esters induces DNA synthesis and protein phosphorylations in glomerular mesangial cells.Purification and internal amino acid sequence of the 80 kDa protein kinase C substrate from Swiss 3T3 fibroblasts. Homology with substrates from brain.Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca2+ mobilization or inositol phosphate accumulation.Bombesin receptor in membranes from Swiss 3T3 cells. Binding characteristics, affinity labelling and modulation by guanine nucleotides.Phosphorylation and redistribution of the phosphatidylinositol-transfer protein in phorbol 12-myristate 13-acetate- and bombesin-stimulated Swiss mouse 3T3 fibroblasts.[Arg6,D-Trp7,9,NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism.
P2860
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P2860
Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Early events elicited by bombe ...... idermal growth factor binding.
@en
type
label
Early events elicited by bombe ...... idermal growth factor binding.
@en
prefLabel
Early events elicited by bombe ...... idermal growth factor binding.
@en
P2093
P2860
P356
P1476
Early events elicited by bombe ...... idermal growth factor binding.
@en
P2093
Rozengurt E
Sinnett-Smith JW
P2860
P304
P356
10.1083/JCB.102.6.2211
P407
P577
1986-06-01T00:00:00Z