about
Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specificStructure of the small G protein Cdc42 bound to the GTPase-binding domain of ACKThe Rac1 polybasic region is required for interaction with its effector PRK1Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK)Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein bindingThe solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding siteHydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomesStructure of the HP1 chromodomain bound to histone H3 methylated at lysine 9Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding siteMolecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAMStructural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatinStructure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoproteinThe structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for functionStructure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopyThe RalB-RLIP76 Complex Reveals a Novel Mode of Ral-Effector InteractionAtomic structure and hierarchical assembly of a cross- amyloid fibrilThe Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the MembraneInvestigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.(1)H, (13)C and (15)N resonance assignments of the Cdc42-binding domain of TOCA1Integral membrane protein structure determination using pseudocontact shifts.A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACKRLIP76 (RalBP1): The first piece of the structural puzzle.Role of intermolecular forces in defining material properties of protein nanofibrils.Structures of Ras superfamily effector complexes: What have we learnt in two decades?Inhibition of Ral GTPases Using a Stapled Peptide Approach.Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover.Thermodynamic mapping of effector protein interfaces with RalA and RalB.Specificity determinants on Cdc42 for binding its effector protein ACK.1H, 13C and 15N resonance assignments of the GTPase-activating (GAP) and Ral binding domains (GBD) of RLIP76 (RalBP1).Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase.Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.Resonance assignments for the RLIP76 Ral binding domain in its free form and in complex with the small G protein RalB.Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2.The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes.Bioblockades join the assault on small G protein signalling.Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.In support of the BMRB.Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Helen R. Mott
@ast
Helen R. Mott
@en
Helen R. Mott
@es
Helen R. Mott
@sl
type
label
Helen R. Mott
@ast
Helen R. Mott
@en
Helen R. Mott
@es
Helen R. Mott
@sl
prefLabel
Helen R. Mott
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Helen R. Mott
@en
Helen R. Mott
@es
Helen R. Mott
@sl
P106
P1153
7003688196
P21
P31
P496
0000-0002-7890-7097