A novel single-chain antibody fragment for detection of mannose 6-phosphate-containing proteins: application in mucolipidosis type II patients and mice
about
A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolismMass spectrometric analysis of neutral and anionic N-glycans from a Dictyostelium discoideum model for human congenital disorder of glycosylation CDG ILSite-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription controlT47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys319 in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond FormationLysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†A case of mucolipidosis II presenting with prenatal skeletal dysplasia and severe secondary hyperparathyroidism at birth.Exploring the unique N-glycome of the opportunistic human pathogen Acanthamoeba.Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.Proteolytic processing of the gamma-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages.Arylsulfatase K, a novel lysosomal sulfatase.Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting.Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors.Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells
P2860
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P2860
A novel single-chain antibody fragment for detection of mannose 6-phosphate-containing proteins: application in mucolipidosis type II patients and mice
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
A novel single-chain antibody ...... osis type II patients and mice
@en
type
label
A novel single-chain antibody ...... osis type II patients and mice
@en
prefLabel
A novel single-chain antibody ...... osis type II patients and mice
@en
P2093
P2860
P1476
A novel single-chain antibody ...... osis type II patients and mice
@en
P2093
Giovanna Galliciotti
Katrin Kollmann
Sven Müller-Loennies
Thomas Braulke
P2860
P304
P356
10.2353/AJPATH.2010.090954
P407
P577
2010-05-14T00:00:00Z