KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I.
about
Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neuronsKB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment.Involvement of the sodium-calcium exchanger 3 (NCX3) in ziram-induced calcium dysregulation and toxicity.Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutationIfenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neuronsNa+-induced Ca2+ influx through reverse mode of Na+-Ca2+ exchanger in mouse ventricular cardiomyocyte.Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitisVesicular uptake and exocytosis of L-aspartate is independent of sialin.Calcium dependence of damage to mouse motor nerve terminals following oxygen/glucose deprivation.Calcium handling precedes cardiac differentiation to initiate the first heartbeatNeuronal activity and glutamate uptake decrease mitochondrial mobility in astrocytes and position mitochondria near glutamate transportersCollapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.KB-R7943, a plasma membrane Na(+)/Ca(2+) exchanger inhibitor, blocks opening of the mitochondrial permeability transition pore.Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells.Targeting calcium signaling in cancer therapy.Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchangerHigh potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex.
P2860
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P2860
KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
KB-R7943, an inhibitor of the ...... ibits mitochondrial complex I.
@en
type
label
KB-R7943, an inhibitor of the ...... ibits mitochondrial complex I.
@en
prefLabel
KB-R7943, an inhibitor of the ...... ibits mitochondrial complex I.
@en
P2093
P2860
P1476
KB-R7943, an inhibitor of the ...... hibits mitochondrial complex I
@en
P2093
Matthew K Brittain
Nickolay Brustovetsky
Patrick L Sheets
Tatiana Brustovetsky
Theodore R Cummins
P2860
P304
P356
10.1111/J.1476-5381.2010.01054.X
P407
P577
2011-01-01T00:00:00Z