VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
about
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioidsWhy we scratch an itch: the molecules, cells and circuits of itchThe sacral networks and neural pathways used to elicit lumbar motor rhythm in the rodent spinal cordGenetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?Basic mechanisms of itch.The cell biology of acute itchA monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch reliefTransient receptor potential channels as therapeutic targetsTlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptorsIncoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptorsThe multiple pathways for itch and their interactions with painVesicular glutamate transporter 2 is required for the respiratory and parasympathetic activation produced by optogenetic stimulation of catecholaminergic neurons in the rostral ventrolateral medulla of mice in vivoNeural processing of itch.A subpopulation of nociceptors specifically linked to itchActivity-dependent silencing reveals functionally distinct itch-generating sensory neurons.Chronic itch development in sensory neurons requires BRAF signaling pathways.Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male miceThe peripheral and central mechanisms underlying itchRecent advances in the management of pruritus in chronic liver diseasesMolecular signatures of mouse TRPV1-lineage neurons revealed by RNA-Seq transcriptome analysis.Itch mechanisms and circuits.Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuliVGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.Neurochemical properties of the synapses in the pathways of orofacial nociceptive reflexesExpression of vesicular glutamate transporters VGLUT1 and VGLUT2 in the rat dental pulp and trigeminal ganglion following inflammation.Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain.Identification of spinal circuits transmitting and gating mechanical painVGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferentsSome lumbar sympathetic neurons develop a glutamatergic phenotype after peripheral axotomy with a note on VGLUT₂-positive perineuronal basketsExpression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn.Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord.Facial injections of pruritogens or algogens elicit distinct behavior responses in rats and excite overlapping populations of primary sensory and trigeminal subnucleus caudalis neurons.Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.Sensory responses to injection and punctate application of capsaicin and histamine to the skin.Non-peptidergic small diameter primary afferents expressing VGluT2 project to lamina I of mouse spinal dorsal hornGenetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system.The molecular and cellular basis of thermosensation in mammals.Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice.Molecular and cellular mechanisms that initiate pain and itch.
P2860
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P2860
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
VGLUT2-dependent glutamate rel ...... o sense pain and suppress itch
@en
type
label
VGLUT2-dependent glutamate rel ...... o sense pain and suppress itch
@en
prefLabel
VGLUT2-dependent glutamate rel ...... o sense pain and suppress itch
@en
P2093
P2860
P50
P1433
P1476
VGLUT2-dependent glutamate rel ...... o sense pain and suppress itch
@en
P2093
Bradford B Lowell
Claudia Lopes
Ling Zhang
Omar Abdel Samad
P2860
P304
P356
10.1016/J.NEURON.2010.09.008
P407
P577
2010-11-01T00:00:00Z