Human jejunal effective permeability and its correlation with preclinical drug absorption models.
about
Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption.Gastrointestinal absorption of drugs: methods and studies.Intestinal permeability of metformin using single-pass intestinal perfusion in rats.General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs.The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique.The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension.Intestinal permeability and its relevance for absorption and elimination.Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption.Modeling kinetics of subcellular disposition of chemicals.Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapyGlucosinolates in Brassica vegetables: the influence of the food supply chain on intake, bioavailability and human health.Application of method suitability for drug permeability classification.The solubility-permeability interplay and its implications in formulation design and development for poorly soluble drugs.The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug developmentExperimental models for predicting drug absorption and metabolism.Pre-clinical pharmacokinetics of the cyclooxygenase-inhibiting nitric oxide donor (CINOD) AZD3582.Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.The role of permeability in drug ADME/PK, interactions and toxicity--presentation of a permeability-based classification system (PCS) for prediction of ADME/PK in humans.Modulation of uptake of organic cationic drugs in cultured human colon adenocarcinoma Caco-2 cells by an ecto-alkaline phosphatase activity.Arsenic-containing hydrocarbons and arsenic-containing fatty acids: Transfer across and presystemic metabolism in the Caco-2 intestinal barrier model.Food Effect in Humans: Predicting the Risk Through In Vitro Dissolution and In Vivo Pharmacokinetic Models.Impact of culture media glucose levels on the intestinal uptake of organic cations.Chitosan based atorvastatin nanocrystals: effect of cationic charge on particle size, formulation stability, and in-vivo efficacy.The fraction dose absorbed, in humans, and high jejunal human permeability relationship.The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans.Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats.Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation.The advantages of the Ussing chamber in drug absorption studies.Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells.Modulation of MPP+ uptake by procyanidins in Caco-2 cells: involvement of oxidation/reduction reactions.Kinetic modelling of passive transport and active efflux of a fluoroquinolone across Caco-2 cells using a compartmental approach in NONMEM.Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-D-glucuronide in rat intestine and Caco-2 cells.Gender-related differences on P-glycoprotein-mediated drug intestinal transport in rats.On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic 'body-on-a-chip' devices.Intestinal drug transport: ex vivo evaluation of the interactions between ABC transporters and anthelmintic molecules
P2860
Q27313187-34DFCEAD-3B55-4D03-B83B-7E552EE34433Q33607303-556BB15A-4BFB-4260-8175-81F9C6F27130Q33867468-7E5AEC45-0BD3-4D63-97B4-9F64E8DD6D1BQ34656231-E40E0479-7A36-46A0-8B57-6E6C4F59F109Q35846680-E03F6923-B049-47F3-B6B8-9486E110D4EDQ36088451-A09F1815-298F-45EB-A625-ACAD0DC8E954Q36985043-FE720CE7-C83B-4B62-A06C-0A5A6B1F3435Q37058658-7A96953A-F5FC-48DA-BBCC-E4E619FB39A2Q37194304-B3AC006C-3D6D-44A7-BBC8-44C95506066FQ37226769-F24732B6-7F9F-4334-A094-F33335D4FB0EQ37335361-EBB8F222-CD31-408E-8F90-07DAE03CF2BAQ37784730-7B3ACC87-8974-4063-B7F1-4B8523F5037FQ37990748-921BF9DA-D4B1-4505-B82C-B3F7BB6620F8Q38059421-94486E51-7502-4106-A140-02615072493EQ38107970-21CDB859-4B3C-40E0-AAFE-60D8A012A99CQ39717253-D67DA814-AE21-4230-B4AF-39DD049F66C9Q39777927-057B4CCC-AC2C-4B5A-900D-6F82889C39D3Q39809409-9405387C-0E77-462D-B40F-EB7507C40EA1Q40694546-08ED2243-0959-4872-84AD-38CE2471CB52Q40759369-D25C13A3-B133-4DC4-9DDF-9306966B6ABFQ40987176-C762E4CA-2E30-4274-96EE-3177556F35A0Q41979708-A4D6DEC0-F07C-41FF-995D-215CA0575FD1Q42029428-A89D8C5F-D346-4C65-91F2-2B08F4FE75F2Q42131253-788C7A8F-2490-44F0-A711-B0428CE8AD08Q43985265-A4304F54-F5D2-4581-B541-C5B0D5F044B9Q44720795-A9D12764-6C31-44DF-90F0-8F91DAD8A103Q44867985-1A07148A-6150-4589-A738-956F0406C797Q46644570-4F136239-DEEF-497E-A6F0-BFBEE69C44CFQ46727483-A6374F89-F9D3-4D82-BE00-323542267589Q46858672-DA166BCA-07D2-42BC-A206-863E7366CFB7Q46897790-E693AEA5-C32E-4CFB-87F3-F2CA64E91861Q47625097-AE0B2838-13C1-4D57-82D7-64A122285CEBQ51475986-7DB63C20-7286-4C8F-BFC7-1E9031A2A25EQ51538333-CBFF1DA2-6F28-434B-B5E9-8AC8D42A7E65Q57109850-6DB63680-CC9E-40E3-8382-B1383127D4C9
P2860
Human jejunal effective permeability and its correlation with preclinical drug absorption models.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Human jejunal effective permea ...... inical drug absorption models.
@en
type
label
Human jejunal effective permea ...... inical drug absorption models.
@en
prefLabel
Human jejunal effective permea ...... inical drug absorption models.
@en
P2860
P1476
Human jejunal effective permea ...... inical drug absorption models.
@en
P2093
Lennernäs H
P2860
P304
P356
10.1111/J.2042-7158.1997.TB06084.X
P577
1997-07-01T00:00:00Z