Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.

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Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila.

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Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.

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Wfs1- deficient rats develop p ...... hy and medullary degeneration.

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Wfs1- deficient rats develop p ...... hy and medullary degeneration.

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Allen Kaasik

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Andres Piirsoo

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Eero Vasar

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Indrek Heinla

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Maarja Toots

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Mait Nigul

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Mario Plaas

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Riho Meier

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Riin Reimets

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Toomas Jagomäe

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P2860

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells

Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1

Wolfram Syndrome: Diagnosis, Management, and Treatment

Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome

User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability

Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats

Neuroimaging evidence of deficient axon myelination in Wolfram syndrome.

A practical guide to rodent islet isolation and assessment

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Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.

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P2860

P2860

Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.

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