Structure of a modular polyketide synthase. - Wikidata - wikimedia - TriplyDB

Structure of a modular polyketide synthase.

Structure of a modular polyketide synthase.

http://www.wikidata.org/entity/Q41608053

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Accessing Nature's diversity through metabolic engineering and synthetic biology Recent Advances in Understanding and Engineering Polyketide Synthesis Bioinspired iterative synthesis of polyketides Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases Architecture of the polyketide synthase module: surprises from electron cryo-microscopy Recent advances in the elucidation of enzymatic function in natural product biosynthesis Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly Sticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthase X-ray Scattering Studies of Protein Structural Dynamics.Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system.Probing the phosphopantetheine arm conformations of acyl carrier proteins using vibrational spectroscopy.Fungal polyketide engineering comes of age.Chemical probes for the functionalization of polyketide intermediates.A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate.Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination Multimodular type I polyketide synthases in algae evolve by module duplications and displacement of AT domains in trans.Synthetic Biology of Natural Products.Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined Contacts The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.Harnessing natural product assembly lines: structure, promiscuity, and engineering.Reinvigorating natural product combinatorial biosynthesis with synthetic biology Structures of two distinct conformations of holo-non-ribosomal peptide synthetases Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate Uncovering the structures of modular polyketide synthases.Recent advances in the biosynthesis of unusual polyketide synthase substrates.Ester coupling reactions--an enduring challenge in the chemical synthesis of bioactive natural products.Recent advances in combinatorial biosynthesis for drug discovery The structural biology of biosynthetic megaenzymes.Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology.Single-particle cryo-electron microscopy of macromolecular complexes.Biosynthesis of polyketides by trans-AT polyketide synthases.Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects.A Protein Interaction Map of the Kalimantacin Biosynthesis Assembly Line SeMPI: a genome-based secondary metabolite prediction and identification web server.An overview of rapamycin: from discovery to future perspectives.Structure and mechanism of assembly line polyketide synthases.

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P2860

Structure of a modular polyketide synthase.

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Structure of a modular polyketide synthase.

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Structure of a modular polyketide synthase.

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Structure of a modular polyketide synthase.

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Structure of a modular polyketide synthase.

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Alison R H Narayan

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David H Sherman

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Grady R Congdon

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Janet L Smith

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Jonathan R Whicher

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Joseph A Chemler

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Kristina Håkansson

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Somnath Dutta

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Wendi A Hale

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P2860

Mechanism and substrate recognition of human holo ACP synthase

Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor

Negative staining and image classification — powerful tools in modern electron microscopy

Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases

The structure of docking domains in modular polyketide synthases

Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase

A tylosin ketoreductase reveals how chirality is determined in polyketides

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512-517

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10.1038/NATURE13423

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Douglas A. Hansen

Georgios Skiniotis

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2014-06-18T00:00:00Z

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263431060

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