Structure of alpha-latrotoxin oligomers reveals that divalent cation-dependent tetramers form membrane pores.
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Molecular evolution of α-latrotoxin, the exceptionally potent vertebrate neurotoxin in black widow spider venomalpha-Latrotoxin and its receptorsInsecticidal toxins from black widow spider venomNegative staining and image classification — powerful tools in modern electron microscopyAlpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machineryalpha-latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membraneRecent Advances in Research on Widow Spider Venoms and ToxinsThe calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteinsSynaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating propertySpiders of medical importance in the Asia-Pacific: atracotoxin, latrotoxin and related spider neurotoxins.Acylated serine derivatives: a unique class of arthropod pheromones of the Australian redback spider, Latrodectus hasselti.Molecular mechanisms of neurotransmitter release.Recruitment and diversification of an ecdysozoan family of neuropeptide hormones for black widow spider venom expression.Gene structure, regulatory control, and evolution of black widow venom latrotoxins.The venom gland transcriptome of Latrodectus tredecimguttatus revealed by deep sequencing and cDNA library analysis.House spider genome uncovers evolutionary shifts in the diversity and expression of black widow venom proteins associated with extreme toxicityCryo-EM and single particles.Effects of Gene Duplication, Positive Selection, and Shifts in Gene Expression on the Evolution of the Venom Gland Transcriptome in Widow Spiders.Ab initio reconstruction of helical samples with heterogeneity, disorder and coexisting symmetries.Penelope's web: using alpha-latrotoxin to untangle the mysteries of exocytosis.Epithelial cells are sensitive detectors of bacterial pore-forming toxins.alpha-Latrotoxin, acting via two Ca2+-dependent pathways, triggers exocytosis of two pools of synaptic vesicles.Alpha-latrotoxin rescues SNAP-25 from BoNT/A-mediated proteolysis in embryonic stem cell-derived neurons.Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing.Alpha-latrotoxin induces exocytosis by inhibition of voltage-dependent K+ channels and by stimulation of L-type Ca2+ channels via latrophilin in beta-cells.Escherichia coli RNA polymerase core and holoenzyme structures.alpha-latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin.Mutant alpha-latrotoxin (LTXN4C) does not form pores and causes secretion by receptor stimulation: this action does not require neurexins.Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegansA spirochete surface protein uncouples store-operated calcium channels in fibroblasts: a novel cytotoxic mechanism.Trachynilysin, a neurosecretory protein isolated from stonefish (Synanceia trachynis) venom, forms nonselective pores in the membrane of NG108-15 cells.Acylierte Serinderivate: eine einzigartige Klasse von Arthropoden-Pheromonen der Australischen Rotrückenspinne Latrodectus hasseltiLatrophilin, Neurexin, and Their Signaling-deficient Mutants Facilitate α-Latrotoxin Insertion into Membranes but Are Not Involved in Pore Formation
P2860
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P2860
Structure of alpha-latrotoxin oligomers reveals that divalent cation-dependent tetramers form membrane pores.
description
2000 nî lūn-bûn
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2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
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2000年论文
@zh-cn
name
Structure of alpha-latrotoxin ...... tetramers form membrane pores.
@en
type
label
Structure of alpha-latrotoxin ...... tetramers form membrane pores.
@en
prefLabel
Structure of alpha-latrotoxin ...... tetramers form membrane pores.
@en
P2093
P356
P1476
Structure of alpha-latrotoxin ...... tetramers form membrane pores.
@en
P2093
Ushkaryov YA
van Heel M
P2888
P356
10.1038/71247
P577
2000-01-01T00:00:00Z
P5875
P6179
1032067512