p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation.
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The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cellsp38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levelsAlternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificityDeficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cellsA requirement for FGF signalling in the formation of primitive streak-like intermediates from primitive ectoderm in cultureThe receptor tyrosine kinase FGFR2b/KGFR controls early differentiation of human keratinocytesThe protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a.Overexpression of FGF-2 increases cardiac myocyte viability after injury in isolated mouse hearts.Fibroblast growth factor-2 (FGF-2) increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts.Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cellsConstitutive activity and differential localization of p38alpha and p38beta MAPKs in adult mouse brain.Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2Calcium-activated K+ channels increase cell proliferation independent of K+ conductance.Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cellsThe p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell.The tyrosine kinase c-Met contributes to the pro-tumorigenic function of the p38 kinase in human bile duct cholangiocarcinoma cellsRole of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media.Cardiac myocyte cell cycle control in development, disease, and regeneration.Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney developmentHigh Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase ComplexRole of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells.An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation.Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegenerationSatellite Cells and Skeletal Muscle Regeneration.Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus.Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts.Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathwaysFunctional characterization of a novel FGFR2 mutation, E731K, in craniosynostosis.Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts.Early response to ErbB2 over-expression in polarized Caco-2 cells involves partial segregation from ErbB3 by relocalization to the apical surface and initiation of survival signaling.Ligands to FGF receptor 2-IIIb induce proliferation, motility, protection from cell death and cytoskeletal rearrangements in epithelial ovarian cancer cell lines.Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR.ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line.Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation.Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases.A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transductionPhorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation.Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific.
P2860
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P2860
p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
p38 mitogen-activated protein ...... ation but not differentiation.
@en
type
label
p38 mitogen-activated protein ...... ation but not differentiation.
@en
prefLabel
p38 mitogen-activated protein ...... ation but not differentiation.
@en
P2860
P356
P1476
p38 mitogen-activated protein ...... ation but not differentiation.
@en
P2093
P2860
P304
17491-17498
P356
10.1074/JBC.274.25.17491
P407
P577
1999-06-01T00:00:00Z