Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
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Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depressionStructural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotineInteroception and learning: import to understanding and treating diseases and psychopathologiesThe Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine ReceptorsThe enhancement of contextual fear conditioning by ABT-418.Higher susceptibility to halothane modulation in open- than in closed-channel alpha4beta2 nAChR revealed by molecular dynamics simulationsA New and Efficient Approach to the Synthesis of Nicotine and Anabasine Analogues.The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.CATALYTIC ENANTIOSELECTIVE BORANE REDUCTION OF BENZYL OXIMES: PREPARATION OF (S)-1-PYRIDIN-3-YL-ETHYLAMINE BIS HYDROCHLORIDE.Cellular membrane phospholipids act as a depository for quaternary amine containing drugs thus competing with the acetylcholine/nicotinic receptor.Mechanisms of efferent-mediated responses in the turtle posterior crista.α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.Functional recovery of cholinergic basal forebrain neurons under disease conditions: old problems, new solutions?Membrane potential fluorescence: a rapid and highly sensitive assay for nicotinic receptor channel function.Minor structural changes in nicotinoid insecticides confer differential subtype selectivity for mammalian nicotinic acetylcholine receptorsFrom smoking to cancers: novel targets to neuronal nicotinic acetylcholine receptors.Quantification of alpha4beta2* nicotinic receptors in the rat brain with microPET and 2-[18F]F-A-85380Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type.The therapeutic potential of nicotine and nicotinic agonists for weight control.Estimating binding affinities of the nicotinic receptor for low-efficacy ligands using mixtures of agonists and two-dimensional concentration-response relationshipsSynthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography.Nicotinic acetylcholine receptor-mediated responses in medial vestibular and prepositus hypoglossi nuclei neurons showing distinct neurotransmitter phenotypes.N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.Highly enantioselective borane reduction of heteroaryl and heterocyclic ketoxime ethers catalyzed by novel spiroborate ester derived from diphenylvalinol: application to the synthesis of nicotine analogues.Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomographyDevelopment of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography.Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized RatsRecent PET radioligands with optimal brain kinetics for imaging nicotinic acetylcholine receptors.TC-2559 excites dopaminergic neurones in the ventral tegmental area by stimulating alpha4beta2-like nicotinic acetylcholine receptors in anaesthetised rats.Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors.Effect of acute nicotine administration on striatal dopamine output and metabolism in rats kept at different ambient temperatures.Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors.Chemical Composition and Hypotensive Effect of Campomanesia xanthocarpa.Nicotinic modulation of [(3)H]D-aspartate outflow from cultured cerebellar granule cells.Stress degradation studies on varenicline tartrate and development of a validated stability-indicating HPLC method.Nicotinic acetylcholine receptor assays.Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells.Upregulation of [3H]methyllycaconitine binding sites following continuous infusion of nicotine, without changes of alpha7 or alpha6 subunit mRNA: an autoradiography and in situ hybridization study in rat brain.
P2860
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P2860
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
@en
type
label
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
@en
prefLabel
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
@en
P2093
P356
P1476
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
@en
P2093
P304
P356
10.1021/JM970377O
P407
P577
1997-12-01T00:00:00Z