A gamma-carboxyglutamic acid (gamma) variant (gamma 6D, gamma 7D) of human activated protein C displays greatly reduced activity as an anticoagulant.
about
Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in miceStructure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor IX by two-dimensional NMR spectroscopyActivated protein C action in inflammationProtective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C.Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C.The functions of the first epidermal growth factor homology region of human protein C as revealed by a charge-to-alanine scanning mutagenesis investigation.Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor VaA discrete site modulates activation of I domains. Application to integrin alphaMbeta2.Two Drosophila genes that encode the alph and beta subunits of the brain soluble guanylyl cyclase.Highly conserved residue arginine-15 is required for the Ca2+-dependent properties of the gamma-carboxyglutamic acid domain of human anticoagulation protein C and activated protein C.Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.Production of biologically active human protein C in the milk of transgenic mice.The porcine mammary gland as a bioreactor for complex proteins.Affinity purification of biologically active and inactive forms of recombinant human protein C produced in porcine mammary gland.The gamma-carboxylation recognition site is sufficient to direct vitamin K-dependent carboxylation on an adjacent glutamate-rich region of thrombin in a propeptide-thrombin chimera.
P2860
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P2860
A gamma-carboxyglutamic acid (gamma) variant (gamma 6D, gamma 7D) of human activated protein C displays greatly reduced activity as an anticoagulant.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
A gamma-carboxyglutamic acid ( ...... activity as an anticoagulant.
@en
type
label
A gamma-carboxyglutamic acid ( ...... activity as an anticoagulant.
@en
prefLabel
A gamma-carboxyglutamic acid ( ...... activity as an anticoagulant.
@en
P356
P1433
P1476
A gamma-carboxyglutamic acid ( ...... activity as an anticoagulant.
@en
P2093
Castellino FJ
P304
10828-10834
P356
10.1021/BI00500A016
P407
P577
1990-12-01T00:00:00Z