about
Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the ColonMetabolic pathways in T cell activation and lineage differentiationMyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.IL-18 inhibits growth of murine orthotopic prostate carcinomas via both adaptive and innate immune mechanismsMicrobiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.Anti-interleukin-18 therapy in murine models of inflammatory bowel disease.Development of a unique epigenetic signature during in vivo Th17 differentiation.Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cellsCritical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation.DC activated via dectin-1 convert Treg into IL-17 producersThe development of intestinal lymphoid tissues at the interface of self and microbiota.Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity.Fatty acid metabolism in the regulation of T cell function.IκBNS regulates murine Th17 differentiation during gut inflammation and infection.Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease.Stromal cells as trend-setters for cells migrating into the lymph node.De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.Decreased susceptibility of mice to infection with Listeria monocytogenes in the absence of interleukin-18.RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota.Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.Inflammation recapitulates the ontogeny of lymphoid stromal cells.Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control.Dynamics of gut mucosal and systemic Th1/Th2 cytokine responses in interferon-gamma and interleukin-12p40 knock out mice during primary and challenge Cryptosporidium parvum infectionGeneration of neutralizing mouse anti-mouse IL-18 antibodies for inhibition of inflammatory responses in vivoLineage Relationship Analysis of RORγt+Innate Lymphoid CellsCritical role of the calpain/calpastatin balance in acute allograft rejectionErratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cellsEpithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficileTargeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
ricercatore
@it
հետազոտող
@hy
name
Matthias Lochner
@ast
Matthias Lochner
@en
Matthias Lochner
@es
Matthias Lochner
@sl
type
label
Matthias Lochner
@ast
Matthias Lochner
@en
Matthias Lochner
@es
Matthias Lochner
@sl
prefLabel
Matthias Lochner
@ast
Matthias Lochner
@en
Matthias Lochner
@es
Matthias Lochner
@sl
P214
P1053
L-6963-2015
P106
P21
P214
P31
P3829
P496
0000-0002-7979-5613
P735
P7859
viaf-311437730