The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.
about
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoA novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation.Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane regionThe Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner.Physiological functions of endosomal proteolysis.Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma.The characterization of endosomal insulin degradation intermediates and their sequence of productionChloroquine augments the binding of insulin to its receptor.Uptake and metabolic fate of [HisA8,HisB4,GluB10,HisB27]insulin in rat liver in vivo.Demonstration of specific insulin binding to cytosolic proteins in H35 hepatoma cells, rat liver and skeletal muscle.Rapid cellular removal of a membrane-inserted foreign polypeptide.Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding.
P2860
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P2860
The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
The dissociation and degradati ...... dosomes of rat hepatoma cells.
@en
type
label
The dissociation and degradati ...... dosomes of rat hepatoma cells.
@en
prefLabel
The dissociation and degradati ...... dosomes of rat hepatoma cells.
@en
P1476
The dissociation and degradati ...... dosomes of rat hepatoma cells.
@en
P2093
P304
14828-14835
P407
P577
1990-09-01T00:00:00Z