Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer diseaseMetabolic dysfunction in Alzheimer's disease and related neurodegenerative disordersProtein phosphatases and Alzheimer's diseaseDown-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neuronsNo advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studiesNSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivoBrain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosisDifferential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzaminesEffect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revisedInflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's diseaseCell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C diseaseFocal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice.The microglial "activation" continuum: from innate to adaptive responsesInterleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid.Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitroDoes neuroinflammation fan the flame in neurodegenerative diseases?Antioxidants and Dementia Risk: Consideration through a Cerebrovascular PerspectiveAlzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and GammaPAK in Alzheimer disease, Huntington disease and X-linked mental retardationCharacterization of ionotropic glutamate receptors in human lymphocytesCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersThe Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in DrosophilaNonsteroidal anti-inflammatory drugs are associated with increased neuritic plaquesFerulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic miceIdentification of a novel dehydroergosterol enhancing microglial anti-inflammatory activity in a dairy product fermented with Penicillium candidumInterleukin-1 beta impairs brain derived neurotrophic factor-induced signal transductionSuggesting a Way to Understand the Actual Potential of Anti-Alzheimer's Disease Drugs That Show Promise in Transgenic Mouse ModelsAutoimmune manifestations in the 3xTg-AD model of Alzheimer's disease.GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animalsR-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease.Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse.Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammationChronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.Modulation of microglial innate immunity in Alzheimer's disease by activation of peroxisome proliferator-activated receptor gamma.Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's diseaseMicrosomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer's disease.Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.Why pleiotropic interventions are needed for Alzheimer's disease.NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type
P2860
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P2860
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Ibuprofen suppresses plaque pa ...... model for Alzheimer's disease.
@en
type
label
Ibuprofen suppresses plaque pa ...... model for Alzheimer's disease.
@en
prefLabel
Ibuprofen suppresses plaque pa ...... model for Alzheimer's disease.
@en
P2093
P1476
Ibuprofen suppresses plaque pa ...... model for Alzheimer's disease
@en
P2093
S A Frautschy
P304
P356
10.1523/JNEUROSCI.20-15-05709.2000
P407
P577
2000-08-01T00:00:00Z