Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37.
about
Structural and functional basis of protein phosphatase 5 substrate specificity.A molecular mechanism of chaperone-client recognition.Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System.Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains.Network-based modelling and percolation analysis of conformational dynamics and activation in the CDK2 and CDK4 proteins: dynamic and energetic polarization of the kinase lobes may determine divergence of the regulatory mechanisms.Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation.Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.The HSP90 chaperone machinery.The diverse roles of Hsp90 and where to find them.Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation.Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery.Simvastatin functions as a heat shock protein 90 inhibitor against triple-negative breast cancerStructural insights into the functional diversity of the CDK-cyclin family
P2860
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P2860
Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Molecular Mechanism of Protein ...... me-Specific Cochaperone Cdc37.
@en
type
label
Molecular Mechanism of Protein ...... me-Specific Cochaperone Cdc37.
@en
prefLabel
Molecular Mechanism of Protein ...... me-Specific Cochaperone Cdc37.
@en
P2093
P2860
P1433
P1476
Molecular Mechanism of Protein ...... me-Specific Cochaperone Cdc37.
@en
P2093
Adam Aboalroub
Andrea Diviney
Devon Marshall
Dimitra Keramisanou
Ioannis Gelis
Ralf Landgraf
Randy W Larsen
Ziming Zhang
P2860
P304
P356
10.1016/J.MOLCEL.2016.04.005
P50
P577
2016-04-01T00:00:00Z