A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition.
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Temperature-dependences of the kinetics of reactions of papain and actinidin with a series of reactivity probes differing in key molecular recognition featuresStructure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by tDependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides.Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain.Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin.The structural origins of the unusual specificities observed in the isolation of chymopapain M and actinidin by covalent chromatography and the lack of inhibition of chymopapain M by cystatin.
P2860
A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition.
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1990 nî lūn-bûn
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1990年の論文
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1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
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1990年论文
@wuu
1990年论文
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1990年论文
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name
A re-appraisal of the structur ...... n a time-dependent inhibition.
@en
type
label
A re-appraisal of the structur ...... n a time-dependent inhibition.
@en
prefLabel
A re-appraisal of the structur ...... n a time-dependent inhibition.
@en
P2093
P2860
P356
P1433
P1476
A re-appraisal of the structur ...... n a time-dependent inhibition.
@en
P2093
Brocklehurst K
Kowlessur D
Templeton W
P2860
P304
P356
10.1042/BJ2660645
P407
P577
1990-03-01T00:00:00Z