Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells.
about
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cellsIL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cellsAntiviral CD4+ memory T cells are IL-15 dependentInfection as an Environmental Trigger of Multiple Sclerosis Disease ExacerbationCD8(+)CD122(+) T-Cells: A Newly Emerging Regulator with Central Memory Cell PhenotypesLy49 receptors: innate and adaptive immune paradigmsT cell memory in the context of persistent herpes viral infectionsThe suppression of immune system disorders by passive attritionNew insights into the regulation of T cells by gamma(c) family cytokinesDiacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8+ T Cells with Broad Antitumor Capacity.Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cellsGlobal transcriptome-wide analysis of CIK cells identify distinct roles of IL-2 and IL-15 in acquisition of cytotoxic capacity against tumor.Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokinesStrategies to use immune modulators in therapeutic vaccines against cancerCD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection.Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma modelSinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.IL-15 augments TCR-induced CD4+ T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4+ T cells.TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses.CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice.Regulating functional cell fates in CD8 T cells.Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunitySurviving the crash: transitioning from effector to memory CD8+ T cell.IL-15R alpha expression on CD8+ T cells is dispensable for T cell memoryGammaherpesvirus persistence alters key CD8 T-cell memory characteristics and enhances antiviral protectionCD40 is required for protective immunity against liver stage Plasmodium infectionIL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory.Different functional capacities of latent and lytic antigen-specific CD8 T cells in murine gammaherpesvirus infection.In remembrance of things past: memory T cells and transplant rejection.Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells.TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4⁺ memory T cell loss in SIVmac251-challenged rhesus macaques.Molecular adjuvants for mucosal immunity.Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment.Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1β-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes.A push-pull vaccine strategy using Toll-like receptor ligands, IL-15, and blockade of negative regulation to improve the quality and quantity of T cell immune responses.Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model.
P2860
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P2860
Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Interleukin 15 controls both p ...... mory-phenotype CD8(+) T cells.
@en
type
label
Interleukin 15 controls both p ...... mory-phenotype CD8(+) T cells.
@en
prefLabel
Interleukin 15 controls both p ...... mory-phenotype CD8(+) T cells.
@en
P2093
P2860
P356
P1476
Interleukin 15 controls both p ...... mory-phenotype CD8(+) T cells.
@en
P2093
Adam D Judge
Charles D Surh
Hideki Fujii
Xiaohong Zhang
P2860
P304
P356
10.1084/JEM.20020772
P407
P577
2002-10-01T00:00:00Z