Shear stress and shear rate differentially affect the multi-step process of leukocyte-facilitated melanoma adhesion
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Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells.Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCα-p38-SP-1 pathway.Biomechanics: cell research and applications for the next decadeApplication of Population Dynamics to Study Heterotypic Cell Aggregations in the Near-Wall Region of a Shear Flow.Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis developmentStudy of local hydrodynamic environment in cell-substrate adhesion using side-view μPIV technologyC6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation.Determining beta2-integrin and intercellular adhesion molecule 1 binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay.Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditionsIntegrin VLA-4 enhances sialyl-Lewisx/a-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions.Two-dimensional kinetics of beta 2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow.Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation.Effects of the Tumor-Leukocyte Microenvironment on Melanoma-Neutrophil Adhesion to the Endothelium in a Shear Flow.The roles of platelet GPIIb/IIIa and alphavbeta3 integrins during HeLa cells adhesion, migration, and invasion to monolayer endothelium under static and dynamic shear flow.Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastasesImmunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development.Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells.Microvascular transport and tumor cell adhesion in the microcirculationAdhesion receptors as therapeutic targets for circulating tumor cells.Advanced technologies for studying circulating tumor cells at the protein level.CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells.Feasibility and constraints of particle targeting using the antigen-antibody interaction.A dynamic model of chemoattractant-induced cell migration.Sequential binding of αVβ3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils.Asymmetry of blood flow and cancer cell adhesion in a microchannel with symmetric bifurcation and confluence.Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model.Coupled Flow-Structure-Biochemistry Simulations of Dynamic Systems of Blood Cells Using an Adaptive Surface Tracking Method.A multichannel dampened flow system for studies on shear stress-mediated mechanotransduction.Hydrodynamic shear rate regulates melanoma-leukocyte aggregation, melanoma adhesion to the endothelium, and subsequent extravasationA microfluidic platform for drug screening in a 3D cancer microenvironment.Kinetics analysis of binding between melanoma cells and neutrophils.Melanoma cell extravasation under flow conditions is modulated by leukocytes and endogenously produced interleukin 8.Tumor cell extravasation mediated by leukocyte adhesion is shear rate dependent on IL-8 signaling.
P2860
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P2860
Shear stress and shear rate differentially affect the multi-step process of leukocyte-facilitated melanoma adhesion
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Shear stress and shear rate di ...... -facilitated melanoma adhesion
@en
type
label
Shear stress and shear rate di ...... -facilitated melanoma adhesion
@en
prefLabel
Shear stress and shear rate di ...... -facilitated melanoma adhesion
@en
P2093
P2860
P1476
Shear stress and shear rate di ...... -facilitated melanoma adhesion
@en
P2093
Cheng Dong
Margaret J Slattery
Shile Liang
P2860
P304
P356
10.1016/J.YEXCR.2005.07.028
P407
P577
2005-09-09T00:00:00Z