Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. - Wikidata - wikimedia - TriplyDB

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.

http://www.wikidata.org/entity/Q41775948

about

Epigenetic regulators and their impact on therapy in acute myeloid leukemia Functions of TET Proteins in Hematopoietic Transformation Connections between TET proteins and aberrant DNA modification in cancer The TET2 interactors and their links to hematological malignancies Role of TET enzymes in DNA methylation, development, and cancer Diverse involvement of EZH2 in cancer epigenetics CAPRI: efficient inference of cancer progression models from cross-sectional data.Prognostic value of isocitrate dehydrogenase mutations in myelodysplastic syndromes: a retrospective cohort study and meta-analysis.Evaluation of allelic strength of human TET2 mutations and cooperation between Tet2 knockdown and oncogenic Nras mutation.Regulation and Role of EZH2 in Cancer The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers Myelodysplasia is in the niche: novel concepts and emerging therapies.The molecular basis of myeloid malignancies.SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.TET proteins and 5-methylcytosine oxidation in hematological cancers Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma.DNA methylation and hydroxymethylation in hematologic differentiation and transformation.Targeting EZH2 and PRC2 dependence as novel anticancer therapy.Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm.DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity Peripheral blood cell-free DNA is an alternative tumor DNA source reflecting disease status in myelodysplastic syndromes.Epigenetics of hematopoiesis and hematological malignancies.RNA splicing factors as oncoproteins and tumour suppressors.Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms.EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells.Stem cell origin of myelodysplastic syndromes.Integrating genetics and epigenetics in myelodysplastic syndromes: advances in pathogenesis and disease evolution.EZH2: an emerging role in melanoma biology and strategies for targeted therapy.The mechanistic role of DNA methylation in myeloid leukemogenesis.Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination -7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity.Epigenetics of hematopoietic stem cell aging and disease.New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.Epigenetic modifiers in normal and malignant hematopoiesis.Context-dependent actions of Polycomb repressors in cancer.Therapy-related myeloid neoplasms: when genetics and environment collide.Stem and progenitor cell alterations in myelodysplastic syndromes.

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P2860

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.

http://www.wikidata.org/entity/Q41775948

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Concurrent loss of Ezh2 and Te ...... of myelodysplastic disorders.

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type

label

Concurrent loss of Ezh2 and Te ...... of myelodysplastic disorders.

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prefLabel

Concurrent loss of Ezh2 and Te ...... of myelodysplastic disorders.

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Journal of Experimental Medicine

P1476

Concurrent loss of Ezh2 and Te ...... of myelodysplastic disorders.

@en

P2093

Asuka Kamio

http://www.w3.org/2001/XMLSchema#string

Atsunori Saraya

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Atsushi Iwama

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Chiaki Nakaseko

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Genta Nagae

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George R Wendt

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Goro Sashida

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Hiroyuki Aburatani

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Kazuya Shimoda

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Koutaro Yokote

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P2860

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins

Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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10.1084/JEM.20131144

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12

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210

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Haruhiko Koseki

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2013-11-11T00:00:00Z

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258445597

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