Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling
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Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activationPP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replicationProtein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6PP4 is essential for germinal center formation and class switch recombination in miceThe phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating LckProtein Ser/Thr phosphatases--the ugly ducklings of cell signalling.Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunityThe serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of immunoglobulin VDJ recombination.Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance.Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylationT cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4.Protein phosphatases PP2A, PP4 and PP6: mediators and regulators in development and responses to environmental cues.Protein phosphatase 4 plays dual roles during cell proliferation.Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes.Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin.Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.Response to DNA damage: why do we need to focus on protein phosphatases?Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair.The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes.Protein DHX38 is a novel inhibitor of protein phosphatase 4
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Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling
description
2006 nî lūn-bûn
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2006年の論文
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2006年論文
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2006年論文
@zh-hant
2006年論文
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2006年論文
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2006年論文
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2006年论文
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2006年论文
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2006年论文
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name
Conditional knockout mice reve ...... pre-T-cell receptor signaling
@en
type
label
Conditional knockout mice reve ...... pre-T-cell receptor signaling
@en
prefLabel
Conditional knockout mice reve ...... pre-T-cell receptor signaling
@en
P2093
P2860
P356
P1476
Conditional knockout mice reve ...... pre-T-cell receptor signaling
@en
P2093
Jr-Wen Shui
Mickey C-T Hu
Tse-Hua Tan
P2860
P356
10.1128/MCB.00799-06
P407
P577
2006-10-23T00:00:00Z