about
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthaseThe development and application of a novel safety-catch linker for BOC-based assembly of libraries of cyclic peptides.A versatile synthetic approach to peptidyl privileged structures using a "safety-catch" linker.Proteolysis of human hemoglobin by schistosome cathepsin D.Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel.A gradient descent algorithm for minimizing amino acid coupling reactions when synthesizing cyclic-peptide libraries.Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification.Library of biphenyl privileged substructures using a safety-catch linker approach.The combinatorial synthesis of bicyclic privileged structures or privileged substructures.Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo.Sigma-class glutathione transferases.Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases.Proteolytic degradation of host hemoglobin by schistosomes.Intramolecular disulphide bond arrangements in nonhomologous proteins.Increased site 1 affinity improves biopotency of porcine growth hormone. Evidence against diffusion dependent receptor dimerization.A safety catch linker for Fmoc-based assembly of constrained cyclic peptides.Conformational searching using a population-based incremental learning algorithm.Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions.Topological side-chain classification of beta-turns: ideal motifs for peptidomimetic development.A subset-orientated algorithm for minimizing the number of steps required for synthesis of cyclic-peptide libraries.An activated O --> N acyl transfer auxiliary: efficient amide-backbone substitution of hindered "difficult" peptides.Difficult Macrocyclizations: New Strategies for Synthesizing Highly Strained Cyclic TetrapeptidesA Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1†,§Exploring privileged structures: the combinatorial synthesis of cyclic peptides
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description
hulumtues
@sq
researcher
@en
wetenschapper
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հետազոտող
@hy
name
Mark L. Smythe
@ast
Mark L. Smythe
@en
Mark L. Smythe
@es
Mark L. Smythe
@nl
Mark L. Smythe
@sl
type
label
Mark L. Smythe
@ast
Mark L. Smythe
@en
Mark L. Smythe
@es
Mark L. Smythe
@nl
Mark L. Smythe
@sl
prefLabel
Mark L. Smythe
@ast
Mark L. Smythe
@en
Mark L. Smythe
@es
Mark L. Smythe
@nl
Mark L. Smythe
@sl
P106
P1153
7006068868
P21
P2456
P31
P496
0000-0001-7840-1021