Implication of the melanocortin-3 receptor in the regulation of food intake.
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Obesity in the Otsuka Long Evans Tokushima Fatty Rat: Mechanisms and DiscoveriesMelanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the ratMelanocortin 3 receptor has a 5' exon that directs translation of apically localized protein from the second in-frame ATG.Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers.A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage.Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice.Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis.Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2.From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation.Unraveling the central proopiomelanocortin neural circuits.Anorexia in human and experimental animal models: physiological aspects related to neuropeptides.A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist.Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.Microwave-assisted solid-phase synthesis of side-chain to side-chain lactam-bridge cyclic peptides.Synthesis and Pharmacology of α/β(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH2 Sequence.Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor.Ac-Trp-DPhe(p-I)-Arg-Trp-NH2, a 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R), Affects Energy Homeostasis in Male and Female Mice Differently.Comparative in Vivo Investigation of Intrathecal and Intracerebroventricular Administration with Melanocortin Ligands MTII and AGRP into Mice.Synthesis and Structure-Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors.1,2,3-Triazole Rings as a Disulfide Bond Mimetic in Chimeric AGRP-Melanocortin Peptides: Design, Synthesis, and Functional Characterization.Interactions of amylinergic and melanocortinergic systems in the control of food intake and body weight in rodents.Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacolog
P2860
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P2860
Implication of the melanocortin-3 receptor in the regulation of food intake.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Implication of the melanocortin-3 receptor in the regulation of food intake.
@en
type
label
Implication of the melanocortin-3 receptor in the regulation of food intake.
@en
prefLabel
Implication of the melanocortin-3 receptor in the regulation of food intake.
@en
P2093
P2860
P1476
Implication of the melanocortin-3 receptor in the regulation of food intake
@en
P2093
Amanda M Shaw
Bettina Proneth
Boman G Irani
Carrie Haskell-Luevano
Deborah J Clegg
Hossein N Yarandi
Jerry R Holder
Marcus C Moore
Rayna M Bauzo
Stephen C Benoit
P2860
P356
10.1016/J.EJPHAR.2010.10.101
P407
P50
P577
2011-01-01T00:00:00Z