Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. - Wikidata - wikimedia - TriplyDB

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation.

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation.

http://www.wikidata.org/entity/Q41812724

about

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.Decoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker.Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.

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P2860

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation.

http://www.wikidata.org/entity/Q41812724

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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name

Development of an enzyme-linke ...... vo LRRK2 S935 phosphorylation.

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Development of an enzyme-linke ...... vo LRRK2 S935 phosphorylation.

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Development of an enzyme-linke ...... vo LRRK2 S935 phosphorylation.

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P356

J.JPBA.2012.12.002

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Journal of Pharmaceutical and Biomedical Analysis

P1476

Development of an enzyme-linke ...... vo LRRK2 S935 phosphorylation.

@en

P2093

Diederik W Moechars

http://www.w3.org/2001/XMLSchema#string

Guy Daneels

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Kris Gevaert

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Kristof Van Kolen

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Liesbeth Steegmans

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Lore Delbroek

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Pieter-Jan De Bock

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Raquel da Cunha

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Wim Mandemakers

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P2860

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

Kinase activity of mutant LRRK2 mediates neuronal toxicity

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation

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49-58

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scholarly article

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10.1016/J.JPBA.2012.12.002

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76

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Patrik Verstreken

Bart De Strooper

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234122934

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4196644

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