Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia. - Wikidata - wikimedia - TriplyDB

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

http://www.wikidata.org/entity/Q41818692

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Functions of TET Proteins in Hematopoietic Transformation Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.Role of TET enzymes in DNA methylation, development, and cancer The emerging role of GATA transcription factors in development and disease DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders Emerging concepts of epigenetic dysregulation in hematological malignancies Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2 DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study.miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia.Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.DNA methylation and hydroxymethylation in hematologic differentiation and transformation.Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice Precision medicine for acute myeloid leukemia Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.Epigenetics of hematopoiesis and hematological malignancies.Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia.Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia Diagnosis and Therapy of Acute Myeloid Leukemia in the Era of Molecular Risk Stratification.Mutations in epigenetic modifiers in acute myeloid leukemia and their clinical utility.Biology and relevance of human acute myeloid leukemia stem cells.Roles of IDH1/2 and TET2 mutations in myeloid disorders.Genetic and epigenetic heterogeneity in acute myeloid leukemia.Dysregulation of TET2 in hematologic malignancies.TET2 in Normal and Malignant Hematopoiesis.Epigenetic dysregulation of hematopoietic stem cells and preleukemic state.Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis.Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.

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P2860

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

http://www.wikidata.org/entity/Q41818692

description

2015 nî lūn-bûn

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2015年の論文

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2015年论文

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2015年论文

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2015年论文

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name

Mutational cooperativity linke ...... ion in acute myeloid leukemia.

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type

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Mutational cooperativity linke ...... ion in acute myeloid leukemia.

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Mutational cooperativity linke ...... ion in acute myeloid leukemia.

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J.CCELL.2015.03.009

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Mutational cooperativity linke ...... ion in acute myeloid leukemia.

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Agnes Viale

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Alan H Shih

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Alexander Robertson

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Ari Melnick

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Brittany Woods

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Cem Meydan

http://www.w3.org/2001/XMLSchema#string

Chen Wei

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Chris Mason

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Elisa de Stanchina

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Franck Rapaport

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P2860

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study.

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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502-515

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4

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27

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Martin S Tallman

Elisabeth Paietta

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25873173

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