Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

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Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.

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Q41518288-AD0B29F7-DD60-4A59-BB71-81AD96D4E82A

P2860

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

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http://www.wikidata.org/entity/Q41821577

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

Discovery of the first dual in ...... ophore-based virtual screening

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type

Item

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Discovery of the first dual in ...... ophore-based virtual screening

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Discovery of the first dual in ...... ophore-based virtual screening

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P1476

Discovery of the first dual in ...... ophore-based virtual screening

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Barbara Matuszczak

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Daniela Schuster

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Erik Romp

http://www.w3.org/2001/XMLSchema#string

Gregor Schubert

http://www.w3.org/2001/XMLSchema#string

Zsofia Kutil

http://www.w3.org/2001/XMLSchema#string

P2860

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors

Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography

Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration

Anti-inflammatory effects of aspirin and sodium salicylate

Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model

Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses

Soluble epoxide hydrolase is a therapeutic target for acute inflammation

Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural Database.

Conformer generation with OMEGA: learning from the data set and the analysis of failures.

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srep42751

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42751

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scholarly article

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10.1038/SREP42751

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English

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2017-02-20T00:00:00Z

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1083850275

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28218273

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5317001

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Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

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P2860

P2860

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

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name

type

label

prefLabel

P1433

P1476

P2093

P2860

P2888

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P31

P356

P407

P478

P50

P577

P6179

P698

P932

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P478

P50

P577

P6179

P698

P932